| Title |
Etiology of Insulin Resistance in Youth with Type 2 Diabetes
|
|---|---|
| Published in |
Current Diabetes Reports, November 2012
|
| DOI | 10.1007/s11892-012-0341-0 |
| Pubmed ID | |
| Authors |
Melanie Cree-Green, Taylor M. Triolo, Kristen J. Nadeau |
| Abstract |
Type 2 diabetes (T2DM), historically an adult disease, is now increasingly prevalent in obese youth. Poor diet and increased sedentary behavior contribute to the increasing rates of obesity in youth, yet not all obese children develop T2DM. In general, T2DM is characterized by both insulin resistance (IR) and pancreatic beta-cell insufficiency. In children, IR is related to elevated body mass index (BMI) and pubertal hormones, along with abnormal fat partitioning, elevated free fatty acids, inflammation, and/or mitochondrial dysfunction. Hyperglycemia and T2DM develop when the pancreas cannot match the increased insulin demands resulting from IR. Unique to youth, IR varies with stage of pubertal development, and some children may have resolution of hyperglycemia post-puberty once the IR of puberty resolves. Further understanding of IR, the progression to T2DM in youth, and later outcomes as adults will help direct future therapies and interventions for youth at risk. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| United States | 1 | <1% |
| Unknown | 106 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 21 | 19% |
| Student > Bachelor | 17 | 16% |
| Student > Ph. D. Student | 10 | 9% |
| Researcher | 9 | 8% |
| Student > Postgraduate | 8 | 7% |
| Other | 17 | 16% |
| Unknown | 27 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 27% |
| Nursing and Health Professions | 12 | 11% |
| Agricultural and Biological Sciences | 8 | 7% |
| Sports and Recreations | 6 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
| Other | 18 | 17% |
| Unknown | 32 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2012.
All research outputs
#18,320,524
of 22,685,926 outputs
Outputs from Current Diabetes Reports
#771
of 1,005 outputs
Outputs of similar age
#138,631
of 182,177 outputs
Outputs of similar age from Current Diabetes Reports
#15
of 21 outputs
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