| Title |
Serial CSF sampling over a period of 30 h via an indwelling spinal catheter in healthy volunteers: headache, back pain, tolerability and measured acetylcholine profile
|
|---|---|
| Published in |
European Journal of Clinical Pharmacology, November 2012
|
| DOI | 10.1007/s00228-012-1443-y |
| Pubmed ID | |
| Authors |
Izaak den Daas, Johan Wemer, Khalid Abou Farha, Wim Tamminga, Theo de Boer, Rob Spanjersberg, Michel M. R. F. Struys, Anthony R. Absalom |
| Abstract |
Timed interval cerebrospinal fluid (CSF) sampling by indwelling catheterization can be a valuable corroborative tool for the pharmacokinetic and pharmacodynamic assessment of drugs. CSF sampling in studies on drug candidates for Alzheimer's disease have been conducted in evaluations of the biomarkers acetylcholine (ACh), tau proteins, amyloid precursor protein and beta-amyloid fragments. The primary aim of this study was to study the feasibility and the burden on the healthy volunteers of serial CSF sampling within the contract research organization environment in order to establish a standardized research tool for future drug development studies. |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 37 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 14% |
| Other | 3 | 8% |
| Student > Doctoral Student | 3 | 8% |
| Student > Ph. D. Student | 3 | 8% |
| Professor > Associate Professor | 3 | 8% |
| Other | 9 | 24% |
| Unknown | 11 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 35% |
| Nursing and Health Professions | 5 | 14% |
| Neuroscience | 2 | 5% |
| Chemical Engineering | 1 | 3% |
| Psychology | 1 | 3% |
| Other | 3 | 8% |
| Unknown | 12 | 32% |