| Title |
Global functional connectivity reveals highly significant differences between the vegetative and the minimally conscious state
|
|---|---|
| Published in |
Journal of Neurology, November 2012
|
| DOI | 10.1007/s00415-012-6734-9 |
| Pubmed ID | |
| Authors |
Boris Kotchoubey, Susanne Merz, Simone Lang, Alexandra Markl, Friedemann Müller, Tao Yu, Christian Schwarzbauer |
| Abstract |
A major challenge in the diagnosis of disorders of consciousness is the differential diagnosis between the vegetative state (VS) and the minimally conscious state (MCS). Clinically, VS is defined by complete unawareness, whereas MCS is defined by the presence of inconsistent but clearly discernible behavioural signs of consciousness. In healthy individuals, pain cries have been reported to elicit functional activation within the pain matrix of the brain, which may be interpreted as empathic reaction. In this study, pain cries were presented to six VS patients, six MCS patients, and 17 age-matched healthy controls. Conventional task-related functional magnetic resonance imaging (fMRI) showed no significant differences in functional activation between the VS and MCS groups. In contrast to this negative finding, the application of a novel data-driven technique for the analysis of the brain's global functional connectivity yielded a positive result. The weighted global connectivity (WGC) was significantly greater in the MCS group compared to the VS group (p < 0.05, family-wise error corrected). Using areas of significant WGC differences as 'seed regions' in a secondary connectivity analysis revealed extended functional networks in both MCS and healthy groups, whereas no such long-range functional connections were observed in the VS group. These results demonstrate the potential of functional connectivity MRI (fcMRI) as a clinical tool for differential diagnosis in disorders of consciousness. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 33% |
| United Kingdom | 1 | 17% |
| Mexico | 1 | 17% |
| United States | 1 | 17% |
| Unknown | 1 | 17% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
| Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 3 | 4% |
| Netherlands | 1 | 1% |
| Unknown | 74 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 14 | 18% |
| Student > Ph. D. Student | 13 | 17% |
| Researcher | 13 | 17% |
| Student > Master | 8 | 10% |
| Student > Doctoral Student | 6 | 8% |
| Other | 12 | 15% |
| Unknown | 12 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 21 | 27% |
| Psychology | 21 | 27% |
| Medicine and Dentistry | 10 | 13% |
| Agricultural and Biological Sciences | 5 | 6% |
| Philosophy | 2 | 3% |
| Other | 3 | 4% |
| Unknown | 16 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 October 2014.
All research outputs
#4,948,611
of 24,641,327 outputs
Outputs from Journal of Neurology
#1,276
of 4,840 outputs
Outputs of similar age
#35,192
of 187,773 outputs
Outputs of similar age from Journal of Neurology
#14
of 53 outputs
Altmetric has tracked 24,641,327 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,840 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has gotten more attention than average, scoring higher than 73% of its peers.
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We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.