Title |
Unfavourable cardiovascular disease risk profiles in a cohort of Dutch and British haemophilia patients
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Published in |
Thrombosis and Haemostasis, November 2017
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DOI | 10.1160/th12-05-0332 |
Pubmed ID | |
Authors |
Dietje E Fransen van de Putte, Kathelijn Fischer, Michael Makris, R Campbell Tait, Pratima Chowdary, Peter W Collins, Karina Meijer, Goris Roosendaal, Roger E G Schutgens, Eveline P Mauser-Bunschoten |
Abstract |
Cardiovascular disease (CVD) mortality is reported to be decreased in haemophilia patients, but reports on the prevalence of CVD risk factors are conflicting. A cross-sectional assessment of CVD risk profiles was performed in a large cohort of haemophilia patients. Baseline data on CVD risk factors of 709 Dutch and UK haemophilia patients aged ≥30 years were analysed and compared with the general age-matched male population. CVD risk profiles were assessed using the QRISK®2-2011 and SCORE algorithms. Although QRISK® 2 was only validated in the UK, comparison with SCORE indicated similar properties of QRISK®2 in both Dutch and UK patients (correlation 0.86). Mean age was 49.8 years. Hypertension was more common in haemophilia patients than in the general population (49% vs. 40%), while the prevalences of obesity and hypercholesterolaemia were lower (15 vs. 20% and 44 vs. 68%, respectively), and those of diabetes and smoking were similar. The predicted 10-year QRISK®2 risk was significantly higher in haemophilia patients than in the general population (8.9 vs. 6.7%), indicating more unfavourable cardiovascular disease risk profiles. This increased risk became apparent after the age of 40 years. Our results indicate an increased prevalence of hypertension and overall more unfavourable CVD risk profiles in haemophilia patients compared with the general age-matched male population. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
United States | 1 | 2% |
Netherlands | 1 | 2% |
Denmark | 1 | 2% |
Unknown | 43 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 19% |
Student > Master | 8 | 17% |
Student > Ph. D. Student | 7 | 15% |
Student > Bachelor | 3 | 6% |
Professor | 3 | 6% |
Other | 8 | 17% |
Unknown | 9 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 24 | 51% |
Nursing and Health Professions | 3 | 6% |
Economics, Econometrics and Finance | 3 | 6% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Agricultural and Biological Sciences | 1 | 2% |
Other | 4 | 9% |
Unknown | 10 | 21% |