Title |
Orbitofrontal Dysfunction and Medication Overuse in Patients With Migraine
|
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Published in |
Headache: The Journal of Head & Face Pain, November 2012
|
DOI | 10.1111/j.1526-4610.2012.02277.x |
Pubmed ID | |
Authors |
Bruno Biagianti, Licia Grazzi, Orsola Gambini, Susanna Usai, Riccardo Muffatti, Silvio Scarone, Gennaro Bussone |
Abstract |
Orbitofrontal cortex (OFC) dysfunction and poor decision making have been described in patients with chronic migraine and medication overuse. These neurobiological underpinnings might explain dependency-like behaviors often described in this condition, such as loss of control over painkillers, high rates of relapse after detoxification, and compromised social functioning. We investigate whether the OFC impairment was a persistent trait in migraine, independent of clinical and affective features, a dynamic result of the need to cope with the increased pain and disability, or a temporary consequence of medication overuse. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 33% |
Netherlands | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 57 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 21% |
Student > Doctoral Student | 7 | 12% |
Student > Master | 5 | 9% |
Student > Bachelor | 4 | 7% |
Researcher | 4 | 7% |
Other | 10 | 18% |
Unknown | 15 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 16 | 28% |
Medicine and Dentistry | 11 | 19% |
Nursing and Health Professions | 3 | 5% |
Neuroscience | 3 | 5% |
Agricultural and Biological Sciences | 2 | 4% |
Other | 3 | 5% |
Unknown | 19 | 33% |