Title |
Pandemic influenza A/H1N1 virus infection and TNF, LTA, IL1B, IL6, IL8, and CCLpolymorphisms in Mexican population: a case–control study
|
---|---|
Published in |
BMC Infectious Diseases, November 2012
|
DOI | 10.1186/1471-2334-12-299 |
Pubmed ID | |
Authors |
Guadalupe Morales-García, Ramcés Falfán-Valencia, Román Alejandro García-Ramírez, Ángel Camarena, Alejandra Ramirez-Venegas, Manuel Castillejos-López, Martha Pérez-Rodríguez, César González-Bonilla, Concepción Grajales-Muñíz, Víctor Borja-Aburto, Juan Manuel Mejía-Aranguré |
Abstract |
Some patients have a greater response to viral infection than do others having a similar level of viral replication. Hypercytokinemia is the principal immunopathological mechanism that contributes to a severer clinical course in cases of influenza A/H1N1. The benefit produced, or damage caused, by these cytokines in severe disease is not known. The genes that code for these molecules are polymorphic and certain alleles have been associated with susceptibility to various diseases. The objective of the present study was to determine whether there was an association between polymorphisms of TNF, LTA, IL1B, IL6, IL8, and CCL1 and the infection and severity of the illness caused by the pandemic A/H1N1 in Mexico in 2009. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 1% |
Colombia | 1 | 1% |
Unknown | 68 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 15 | 21% |
Researcher | 14 | 20% |
Student > Master | 10 | 14% |
Student > Doctoral Student | 6 | 9% |
Student > Bachelor | 6 | 9% |
Other | 13 | 19% |
Unknown | 6 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 15 | 21% |
Medicine and Dentistry | 14 | 20% |
Biochemistry, Genetics and Molecular Biology | 10 | 14% |
Social Sciences | 5 | 7% |
Business, Management and Accounting | 4 | 6% |
Other | 12 | 17% |
Unknown | 10 | 14% |