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Novel STIM1‐dependent control of Ca2+ clearance regulates NFAT activity during T‐cell activation

Overview of attention for article published in FASEB Journal, August 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

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1 news outlet
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1 X user

Citations

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24 Mendeley
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Title
Novel STIM1‐dependent control of Ca2+ clearance regulates NFAT activity during T‐cell activation
Published in
FASEB Journal, August 2016
DOI 10.1096/fj.201600532r
Pubmed ID
Authors

Elsie Samakai, Robert Hooper, Kayla A. Martin, Maya Shmurak, Yi Zhang, Dietmar J. Kappes, Italo Tempera, Jonathan Soboloff

Abstract

Antigen presentation to the T cell receptor leads to sustained cytosolic Ca(2+) elevation, which is critical for T-cell activation. We previously showed that in activated T cells, Ca(2+) clearance is inhibited by the endoplasmic reticulum Ca(2+) sensor stromal interacting molecule 1 (STIM1) via association with the plasma membrane Ca(2+)/ATPase 4 (PMCA4) Ca(2+) pump. Having further observed that expression of both proteins is increased in activated T cells, the current study focused on mechanisms regulating both up-regulation of STIM1 and PMCA4 and assessing how this up-regulation contributes to control of Ca(2+) clearance. Using a STIM1 promoter luciferase vector, we found that the zinc finger transcription factors early growth response (EGR) 1 and EGR4, but not EGR2 or EGR3, drive luciferase activity. We further found that neither STIM1 nor PMCA4 is up-regulated when both EGR1 and EGR4 are knocked down using RNA interference. Further, under these conditions, activation-induced Ca(2+) clearance inhibition was eliminated with little effect on Ca(2+) entry. Finally, we found that nuclear factor of activated T cell (NFAT) activity is profoundly attenuated if Ca(2+) clearance is not inhibited by STIM1. These findings reveal a critical role for STIM1-mediated control of Ca(2+) clearance in NFAT induction during T-cell activation.-Samakai, E., Hooper, R., Martin, K. A., Shmurak, M., Zhang, Y., Kappes, D. J., Tempera, I., Soboloff, J. Novel STIM1-dependent control of Ca(2+) clearance regulates NFAT activity during T-cell activation.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 17%
Professor 3 13%
Student > Ph. D. Student 3 13%
Student > Postgraduate 2 8%
Student > Bachelor 2 8%
Other 4 17%
Unknown 6 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 29%
Biochemistry, Genetics and Molecular Biology 5 21%
Immunology and Microbiology 3 13%
Chemical Engineering 1 4%
Medicine and Dentistry 1 4%
Other 1 4%
Unknown 6 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2016.
All research outputs
#3,542,033
of 25,371,288 outputs
Outputs from FASEB Journal
#1,469
of 11,446 outputs
Outputs of similar age
#59,541
of 356,496 outputs
Outputs of similar age from FASEB Journal
#28
of 68 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,446 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 356,496 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.