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Aberrant IgA responses to the gut microbiota during infancy precede asthma and allergy development

Overview of attention for article published in The Journal of Allergy and Clinical Immunology, August 2016
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

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10 news outlets
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46 X users
facebook
5 Facebook pages
googleplus
1 Google+ user

Citations

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123 Dimensions

Readers on

mendeley
286 Mendeley
citeulike
2 CiteULike
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Title
Aberrant IgA responses to the gut microbiota during infancy precede asthma and allergy development
Published in
The Journal of Allergy and Clinical Immunology, August 2016
DOI 10.1016/j.jaci.2016.06.047
Pubmed ID
Authors

Majda Dzidic, Thomas R. Abrahamsson, Alejandro Artacho, Bengt Björkstén, Maria Carmen Collado, Alex Mira, Maria C. Jenmalm

Abstract

While a reduced gut microbiota diversity and low mucosal total IgA levels in infancy have been associated with allergy development, IgA responses to the gut microbiota have not yet been studied. We sought to determine the proportions of IgA coating together with the characterization of the dominant bacteria, bound to IgA or not, in infant stool samples in relation to allergy development. A combination of flow cytometry cell sorting and deep sequencing of the 16S rDNA gene was used to characterize the bacterial recognition patterns by IgA in stool samples collected at 1 and 12 month of age from children staying healthy or developing allergic symptoms up to seven years of age. The children developing allergic manifestations, particularly asthma, during childhood had a lower proportion of IgA bound to fecal bacteria at 12 months of age compared with healthy children. These alterations cannot be attributed to differences in IgA levels or bacterial load between the two groups. Moreover, the bacterial targets of early IgA responses (including the coating of Bacteroides genus) as well as the IgA recognition patterns differed between healthy children and children developing allergic manifestations. Altered IgA recognition patterns in children developing allergy were observed also already at 1 month of age, when the IgA antibodies are predominantly maternally derived in breast fed children. An aberrant IgA responsiveness to the gut microbiota during infancy precedes asthma and allergy development, possibly indicating an impaired mucosal barrier function in allergic children. Aberrant and reduced IgA responses to the gut microbiota during infancy precede development of asthma and allergic disease during the first seven years of life.

X Demographics

X Demographics

The data shown below were collected from the profiles of 46 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 286 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Korea, Republic of 1 <1%
United Kingdom 1 <1%
Denmark 1 <1%
Spain 1 <1%
United States 1 <1%
Unknown 280 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 44 15%
Student > Ph. D. Student 38 13%
Researcher 36 13%
Student > Master 29 10%
Student > Doctoral Student 19 7%
Other 49 17%
Unknown 71 25%
Readers by discipline Count As %
Medicine and Dentistry 59 21%
Immunology and Microbiology 44 15%
Agricultural and Biological Sciences 36 13%
Biochemistry, Genetics and Molecular Biology 25 9%
Nursing and Health Professions 11 4%
Other 28 10%
Unknown 83 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 105. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 September 2019.
All research outputs
#402,590
of 25,394,764 outputs
Outputs from The Journal of Allergy and Clinical Immunology
#343
of 11,247 outputs
Outputs of similar age
#7,979
of 368,016 outputs
Outputs of similar age from The Journal of Allergy and Clinical Immunology
#14
of 142 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,247 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.7. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 368,016 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 142 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.