| Title |
Cannabidiolic acid-mediated selective down-regulation of c-fos in highly aggressive breast cancer MDA-MB-231 cells: possible involvement of its down-regulation in the abrogation of aggressiveness
|
|---|---|
| Published in |
Journal of Natural Medicines, August 2016
|
| DOI | 10.1007/s11418-016-1030-0 |
| Pubmed ID | |
| Authors |
Shuso Takeda, Taichi Himeno, Kazuhiro Kakizoe, Hiroyuki Okazaki, Tomoko Okada, Kazuhito Watanabe, Hironori Aramaki |
| Abstract |
The physiological activities of cannabidiolic acid (CBDA), a component of fiber-type cannabis plants, have been demonstrated and include its function as a protector against external invasion by inducing cannabinoid-mediated necrosis (Shoyama et al., Plant Signal Behav 3:1111-1112, 2008). The biological activities of CBDA have been attracting increasing attention. We previously identified CBDA as an inhibitor of the migration of MDA-MB-231 cells, a widely used human breast cancer cell line in cancer biology, due to its highly aggressive nature. The chemical inhibition and down-regulation of cyclooxygenase-2 (COX-2), the expression of which has been detected in ~40 % of human invasive breast cancers, are suggested to be involved in the CBDA-mediated abrogation of cell migration. However, the molecular mechanism(s) responsible for the CBDA-induced down-regulation of COX-2 in MDA-MB-231 cells have not yet been elucidated. In the present study, we describe a possible mechanism by which CBDA abrogates the expression of COX-2 via the selective down-regulation of c-fos, one component of the activator protein-1 (AP-1) dimer complex, a transcription factor for the positive regulation of the COX-2 gene. |
X Demographics
The data shown below were collected from the profiles of 58 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 16 | 28% |
| Canada | 6 | 10% |
| Spain | 4 | 7% |
| Switzerland | 1 | 2% |
| Japan | 1 | 2% |
| Netherlands | 1 | 2% |
| Bosnia and Herzegovina | 1 | 2% |
| United Kingdom | 1 | 2% |
| Montenegro | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 25 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 47 | 81% |
| Practitioners (doctors, other healthcare professionals) | 5 | 9% |
| Science communicators (journalists, bloggers, editors) | 3 | 5% |
| Scientists | 3 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 75 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 19% |
| Student > Bachelor | 9 | 12% |
| Student > Master | 7 | 9% |
| Student > Doctoral Student | 5 | 7% |
| Other | 4 | 5% |
| Other | 9 | 12% |
| Unknown | 27 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 15% |
| Biochemistry, Genetics and Molecular Biology | 8 | 11% |
| Agricultural and Biological Sciences | 8 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
| Chemical Engineering | 3 | 4% |
| Other | 11 | 15% |
| Unknown | 30 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 83. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 June 2023.
All research outputs
#499,018
of 24,884,310 outputs
Outputs from Journal of Natural Medicines
#2
of 568 outputs
Outputs of similar age
#9,294
of 320,514 outputs
Outputs of similar age from Journal of Natural Medicines
#1
of 11 outputs
Altmetric has tracked 24,884,310 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 568 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.