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Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus

Overview of attention for article published in Neuropharmacology, August 2016
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Title
Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus
Published in
Neuropharmacology, August 2016
DOI 10.1016/j.neuropharm.2016.08.010
Pubmed ID
Authors

Grace France, Diego Fernández-Fernández, Erica S. Burnell, Mark W. Irvine, Daniel T. Monaghan, David E. Jane, Zuner A. Bortolotto, Graham L. Collingridge, Arturas Volianskis

Abstract

In the CA1 area of the hippocampus N-methyl-d-aspartate receptors (NMDARs) mediate the induction of long-term depression (LTD), short-term potentiation (STP) and long-term potentiation (LTP). All of these forms of synaptic plasticity can be readily studied in the juvenile hippocampal slices but the involvement of particular NMDAR-subunits in the induction of these different forms of synaptic plasticity is currently unclear. Here, using NVP-AAM077, Ro 25-6981 and UBP145 to target GluN2A-, 2B- and 2D-containing NMDARs respectively, we show that GluN2B-containing NMDARs (GluN2B) are involved in the induction of LTD, STP and LTP in slices prepared from P14 rat hippocampus. A concentration of Ro (1 μM) that selectively blocks GluN2B-containing diheteromers is able to block LTD. It also inhibits a component of STP without affecting LTP. A higher concentration of Ro (10 μM), that also inhibits GluN2A/B triheteromers, blocks LTP. UBP145 selectively inhibits the Ro-sensitive component of STP whereas NVP inhibits LTP. These data are consistent with a role of GluN2B diheretomers in LTD, a role of both GluN2B and GluN2D containing NMDARs in STP and a role of GluN2A/B triheteromers in LTP.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 97 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 28%
Student > Master 12 12%
Researcher 11 11%
Student > Bachelor 9 9%
Other 8 8%
Other 17 18%
Unknown 13 13%
Readers by discipline Count As %
Neuroscience 38 39%
Agricultural and Biological Sciences 17 18%
Biochemistry, Genetics and Molecular Biology 7 7%
Psychology 5 5%
Chemistry 4 4%
Other 9 9%
Unknown 17 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2016.
All research outputs
#17,285,036
of 25,373,627 outputs
Outputs from Neuropharmacology
#3,561
of 4,817 outputs
Outputs of similar age
#243,133
of 369,184 outputs
Outputs of similar age from Neuropharmacology
#42
of 85 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,817 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 369,184 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 85 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.