Title |
Oestrogen receptor status, treatment and breast cancer prognosis in Icelandic BRCA2 mutation carriers
|
---|---|
Published in |
British Journal of Cancer, August 2016
|
DOI | 10.1038/bjc.2016.249 |
Pubmed ID | |
Authors |
Jon G Jonasson, Olafur A Stefansson, Oskar T Johannsson, Helgi Sigurdsson, Bjarni A Agnarsson, Gudridur H Olafsdottir, Kristin K Alexiusdottir, Hrefna Stefansdottir, Rodrigo Munoz Mitev, Katrin Olafsdottir, Kristrun Olafsdottir, Adalgeir Arason, Vigdis Stefansdottir, Elinborg J Olafsdottir, Rosa B Barkardottir, Jorunn E Eyfjord, Steven A Narod, Laufey Tryggvadóttir |
Abstract |
The impact of an inherited BRCA2 mutation on the prognosis of women with breast cancer has not been well documented. We studied the effects of oestrogen receptor (ER) status, other prognostic factors and treatments on survival in a large cohort of BRCA2 mutation carriers. We identified 285 breast cancer patients with a 999del5 BRCA2 mutation and matched them with 570 non-carrier patients. Clinical information was abstracted from patient charts and pathology records and supplemented by evaluation of tumour grade and ER status using archived tissue specimens. Univariate and multivariate hazard ratios (HR) were estimated for breast cancer-specific survival using Cox regression. The effects of various therapies were studied in patients treated from 1980 to 2012. Among mutation carriers, positive ER status was associated with higher risk of death than negative ER status (HR=1.94; 95% CI=1.22-3.07, P=0.005). The reverse association was seen for non-carriers (HR=0.71; 95% CI: 0.51-0.97; P=0.03). Among BRCA2 carriers, ER-positive status is an adverse prognostic factor. BRCA2 carrier status should be known at the time when treatment decisions are made.British Journal of Cancer advance online publication, 18 August 2016; doi:10.1038/bjc.2016.249 www.bjcancer.com. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 6 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 50% |
Practitioners (doctors, other healthcare professionals) | 2 | 33% |
Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 2% |
Unknown | 51 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 9 | 17% |
Researcher | 9 | 17% |
Student > Ph. D. Student | 6 | 12% |
Student > Bachelor | 3 | 6% |
Student > Doctoral Student | 2 | 4% |
Other | 7 | 13% |
Unknown | 16 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 33% |
Biochemistry, Genetics and Molecular Biology | 5 | 10% |
Agricultural and Biological Sciences | 5 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Business, Management and Accounting | 1 | 2% |
Other | 4 | 8% |
Unknown | 18 | 35% |