Title |
Clusters of male and female Alzheimer’s disease patients in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database
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Published in |
Brain Informatics, March 2016
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DOI | 10.1007/s40708-016-0035-5 |
Pubmed ID | |
Authors |
Dragan Gamberger, Bernard Ženko, Alexis Mitelpunkt, Netta Shachar, Nada Lavrač |
Abstract |
This paper presents homogeneous clusters of patients, identified in the Alzheimer's Disease Neuroimaging Initiative (ADNI) data population of 317 females and 342 males, described by a total of 243 biological and clinical descriptors. Clustering was performed with a novel methodology, which supports identification of patient subpopulations that are homogeneous regarding both clinical and biological descriptors. Properties of the constructed clusters clearly demonstrate the differences between female and male Alzheimer's disease patient groups. The major difference is the existence of two male subpopulations with unexpected values of intracerebral and whole brain volumes. |
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