| Title |
Genetically encoded fluorescent sensors of membrane potential
|
|---|---|
| Published in |
Brain Cell Biology, August 2008
|
| DOI | 10.1007/s11068-008-9026-7 |
| Pubmed ID | |
| Authors |
B. J. Baker, H. Mutoh, D. Dimitrov, W. Akemann, A. Perron, Y. Iwamoto, L. Jin, L. B. Cohen, E. Y. Isacoff, V. A. Pieribone, T. Hughes, T. Knöpfel |
| Abstract |
Imaging activity of neurons in intact brain tissue was conceived several decades ago and, after many years of development, voltage-sensitive dyes now offer the highest spatial and temporal resolution for imaging neuronal functions in the living brain. Further progress in this field is expected from the emergent development of genetically encoded fluorescent sensors of membrane potential. These fluorescent protein (FP) voltage sensors overcome the drawbacks of organic voltage sensitive dyes such as non-specificity of cell staining and the low accessibility of the dye to some cell types. In a transgenic animal, a genetically encoded sensor could in principle be expressed specifically in any cell type and would have the advantage of staining only the cell population determined by the specificity of the promoter used to drive expression. Here we critically review the current status of these developments. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 208 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 2% |
| Germany | 2 | <1% |
| United Kingdom | 2 | <1% |
| France | 1 | <1% |
| Brazil | 1 | <1% |
| Czechia | 1 | <1% |
| Hungary | 1 | <1% |
| Canada | 1 | <1% |
| Switzerland | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 192 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 54 | 26% |
| Student > Ph. D. Student | 46 | 22% |
| Professor > Associate Professor | 20 | 10% |
| Student > Master | 17 | 8% |
| Student > Bachelor | 13 | 6% |
| Other | 36 | 17% |
| Unknown | 22 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 92 | 44% |
| Neuroscience | 26 | 13% |
| Biochemistry, Genetics and Molecular Biology | 17 | 8% |
| Medicine and Dentistry | 13 | 6% |
| Chemistry | 10 | 5% |
| Other | 27 | 13% |
| Unknown | 23 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2023.
All research outputs
#1,426,522
of 22,685,926 outputs
Outputs from Brain Cell Biology
#1
of 15 outputs
Outputs of similar age
#3,522
of 82,309 outputs
Outputs of similar age from Brain Cell Biology
#1
of 3 outputs
Altmetric has tracked 22,685,926 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one scored the same or higher as 14 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 82,309 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them