| Title |
Reduced Glutamate Release in Adult BTBR Mouse Model of Autism Spectrum Disorder
|
|---|---|
| Published in |
Neurochemical Research, August 2016
|
| DOI | 10.1007/s11064-016-2035-5 |
| Pubmed ID | |
| Authors |
Hongen Wei, Yuehong Ma, Caiyun Ding, Guorong Jin, Jianrong Liu, Qiaoqiao Chang, Fengyun Hu, Li Yu |
| Abstract |
Autism spectrum disorder (ASD) is a developmental disorder characterized by impairments in social and communication abilities, as well as by restricted and repetitive behaviors. The BTBR T (+) Itpr3 (tf) (BTBR) mice have emerged as a well characterized and widely used mouse model of a range of ASD-like phenotype, showing deficiencies in social behaviors and unusual ultrasonic vocalizations as well as increased repetitive self-grooming. However, the inherited neurobiological changes that lead to ASD-like behaviors in these mice are incompletely known and still under active investigation. The aim of this study was to further evaluate the structure and neurotransmitter release of the glutamatergic synapse in BTBR mice. C57BL/6J (B6) mice were used as a control strain because of their high level of sociability. The important results showed that the evoked glutamate release in the cerebral cortex of BTBR mice was significantly lower than in B6 mice. And the level of vesicle docking-related protein Syntaxin-1A was reduced in BTBR mice. However, no significant changes were observed in the number of glutamatergic synapse, level of synaptic proteins, density of dendritic spine and postsynaptic density between BTBR mice and B6 mice. Overall, our results suggest that abnormal vesicular glutamate activity may underlie the ASD relevant pathology in the BTBR mice. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 48 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 17% |
| Student > Ph. D. Student | 7 | 15% |
| Researcher | 6 | 13% |
| Student > Bachelor | 5 | 10% |
| Student > Postgraduate | 3 | 6% |
| Other | 8 | 17% |
| Unknown | 11 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 14 | 29% |
| Psychology | 5 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
| Medicine and Dentistry | 3 | 6% |
| Biochemistry, Genetics and Molecular Biology | 2 | 4% |
| Other | 7 | 15% |
| Unknown | 14 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 August 2016.
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#20,337,788
of 22,883,326 outputs
Outputs from Neurochemical Research
#1,694
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#299,792
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Outputs of similar age from Neurochemical Research
#29
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