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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A simple bridging flocculation assay for rapid, sensitive and stringent detection of gene specific DNA methylation
|
|---|---|
| Published in |
Scientific Reports, October 2015
|
| DOI | 10.1038/srep15028 |
| Pubmed ID | |
| Authors |
Eugene J. H. Wee, Thu Ha Ngo, Matt Trau |
| Abstract |
The challenge of bringing DNA methylation biomarkers into clinic is the lack of simple methodologies as most current assays have been developed for research purposes. To address the limitations of current methods, we describe herein a novel methyl-protein domain (MBD) enrichment protocol for simple yet rapid and highly stringent selection of highly methylated DNA from limiting input samples. We then coupled this with a DNA-mediated flocculation assay for rapid and low cost naked-eye binary evaluation of highly methylated genes in cell line and blood DNA. The low resource requirements of our method may enable widespread adoption of DNA methylation-based diagnostics in clinic and may be useful for small-scale research. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| United States | 1 | 3% |
| Unknown | 37 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 23% |
| Student > Ph. D. Student | 6 | 15% |
| Professor > Associate Professor | 5 | 13% |
| Student > Master | 5 | 13% |
| Student > Doctoral Student | 4 | 10% |
| Other | 4 | 10% |
| Unknown | 6 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 7 | 18% |
| Medicine and Dentistry | 5 | 13% |
| Chemistry | 4 | 10% |
| Agricultural and Biological Sciences | 2 | 5% |
| Engineering | 2 | 5% |
| Other | 6 | 15% |
| Unknown | 13 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 August 2016.
All research outputs
#20,337,788
of 22,883,326 outputs
Outputs from Scientific Reports
#105,646
of 123,620 outputs
Outputs of similar age
#234,260
of 279,307 outputs
Outputs of similar age from Scientific Reports
#2,066
of 2,483 outputs
Altmetric has tracked 22,883,326 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 123,620 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 2,483 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.