| Title |
Adult-born dentate granule cells show a critical period of dendritic reorganization and are distinct from developmentally born cells
|
|---|---|
| Published in |
Brain Structure and Function, August 2016
|
| DOI | 10.1007/s00429-016-1285-y |
| Pubmed ID | |
| Authors |
Marcel Beining, Tassilo Jungenitz, Tijana Radic, Thomas Deller, Hermann Cuntz, Peter Jedlicka, Stephan Wolfgang Schwarzacher |
| Abstract |
Adult-born dentate granule cells (abGCs) exhibit a critical developmental phase during function integration. The time window of this phase is debated and whether abGCs become indistinguishable from developmentally born mature granule cells (mGCs) is uncertain. We analyzed complete dendritic reconstructions from abGCs and mGCs using viral labeling. AbGCs from 21-77 days post intrahippocampal injection (dpi) exhibited comparable dendritic arbors, suggesting that structural maturation precedes functional integration. In contrast, significant structural differences were found compared to mGCs: AbGCs had more curved dendrites, more short terminal segments, a different branching pattern, and more proximal terminal branches. Morphological modeling attributed these differences to developmental dendritic pruning and postnatal growth of the dentate gyrus. We further correlated GC morphologies with the responsiveness to unilateral medial perforant path stimulation using the immediate-early gene Arc as a marker of synaptic activation. Only abGCs at 28 and 35 dpi but neither old abGCs nor mGCs responded to stimulation with a remodeling of their dendritic arbor. Summarized, abGCs stay distinct from mGCs and their dendritic arbor can be shaped by afferent activity during a narrow critical time window. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| France | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 64 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 24% |
| Researcher | 12 | 18% |
| Student > Bachelor | 9 | 13% |
| Student > Master | 8 | 12% |
| Student > Doctoral Student | 4 | 6% |
| Other | 8 | 12% |
| Unknown | 10 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 28 | 42% |
| Agricultural and Biological Sciences | 18 | 27% |
| Medicine and Dentistry | 5 | 7% |
| Psychology | 2 | 3% |
| Biochemistry, Genetics and Molecular Biology | 2 | 3% |
| Other | 2 | 3% |
| Unknown | 10 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 January 2022.
All research outputs
#16,454,538
of 24,217,893 outputs
Outputs from Brain Structure and Function
#1,015
of 1,725 outputs
Outputs of similar age
#236,326
of 362,329 outputs
Outputs of similar age from Brain Structure and Function
#30
of 43 outputs
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