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Evidence to Support the Anti-Cancer Effect of Olive Leaf Extract and Future Directions

Overview of attention for article published in Nutrients, August 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

news
4 news outlets
twitter
26 X users
facebook
6 Facebook pages
googleplus
1 Google+ user
video
1 YouTube creator

Citations

dimensions_citation
130 Dimensions

Readers on

mendeley
247 Mendeley
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Title
Evidence to Support the Anti-Cancer Effect of Olive Leaf Extract and Future Directions
Published in
Nutrients, August 2016
DOI 10.3390/nu8080513
Pubmed ID
Authors

Anna Boss, Karen S. Bishop, Gareth Marlow, Matthew P. G. Barnett, Lynnette R. Ferguson

Abstract

The traditional Mediterranean diet (MD) is associated with long life and lower prevalence of cardiovascular disease and cancers. The main components of this diet include high intake of fruit, vegetables, red wine, extra virgin olive oil (EVOO) and fish, low intake of dairy and red meat. Olive oil has gained support as a key effector of health benefits and there is evidence that this relates to the polyphenol content. Olive leaf extract (OLE) contains a higher quantity and variety of polyphenols than those found in EVOO. There are also important structural differences between polyphenols from olive leaf and those from olive fruit that may improve the capacity of OLE to enhance health outcomes. Olive polyphenols have been claimed to play an important protective role in cancer and other inflammation-related diseases. Both inflammatory and cancer cell models have shown that olive leaf polyphenols are anti-inflammatory and protect against DNA damage initiated by free radicals. The various bioactive properties of olive leaf polyphenols are a plausible explanation for the inhibition of progression and development of cancers. The pathways and signaling cascades manipulated include the NF-κB inflammatory response and the oxidative stress response, but the effects of these bioactive components may also result from their action as a phytoestrogen. Due to the similar structure of the olive polyphenols to oestrogens, these have been hypothesized to interact with oestrogen receptors, thereby reducing the prevalence and progression of hormone related cancers. Evidence for the protective effect of olive polyphenols for cancer in humans remains anecdotal and clinical trials are required to substantiate these claims idea. This review aims to amalgamate the current literature regarding bioavailability and mechanisms involved in the potential anti-cancer action of olive leaf polyphenols.

X Demographics

X Demographics

The data shown below were collected from the profiles of 26 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 247 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 247 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 41 17%
Student > Bachelor 32 13%
Researcher 22 9%
Student > Ph. D. Student 17 7%
Professor 8 3%
Other 33 13%
Unknown 94 38%
Readers by discipline Count As %
Agricultural and Biological Sciences 38 15%
Biochemistry, Genetics and Molecular Biology 21 9%
Pharmacology, Toxicology and Pharmaceutical Science 17 7%
Medicine and Dentistry 16 6%
Nursing and Health Professions 15 6%
Other 44 18%
Unknown 96 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 53. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2024.
All research outputs
#806,820
of 25,578,098 outputs
Outputs from Nutrients
#2,272
of 21,757 outputs
Outputs of similar age
#15,266
of 355,676 outputs
Outputs of similar age from Nutrients
#16
of 168 outputs
Altmetric has tracked 25,578,098 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 21,757 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.0. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 355,676 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 168 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.