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C–H functionalization of amines with aryl halides by nickel-photoredox catalysis

Overview of attention for article published in Chemical Science, January 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • Good Attention Score compared to outputs of the same age and source (70th percentile)

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Title
C–H functionalization of amines with aryl halides by nickel-photoredox catalysis
Published in
Chemical Science, January 2016
DOI 10.1039/c6sc02815b
Pubmed ID
Authors

Derek T. Ahneman, Abigail G. Doyle

Abstract

We describe the functionalization of α-amino C-H bonds with aryl halides using a combination of nickel and photoredox catalysis. This direct C-H, C-X coupling uses inexpensive and readily available starting materials to generate benzylic amines, an important class of bioactive molecules. Mechanistically, this method features the direct arylation of α-amino radicals mediated by a nickel catalyst. This reactivity is demonstrated for a range of aryl halides and N-aryl amines, with orthogonal scope to existing C-H activation and photoredox methodologies. We also report reactions with several complex aryl halides, demonstrating the potential utility of this approach in late-stage functionalization.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 150 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 <1%
Unknown 149 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 48 32%
Researcher 20 13%
Student > Bachelor 12 8%
Student > Doctoral Student 11 7%
Student > Master 11 7%
Other 16 11%
Unknown 32 21%
Readers by discipline Count As %
Chemistry 106 71%
Unspecified 4 3%
Engineering 3 2%
Agricultural and Biological Sciences 1 <1%
Chemical Engineering 1 <1%
Other 0 0%
Unknown 35 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 April 2017.
All research outputs
#5,541,594
of 22,883,326 outputs
Outputs from Chemical Science
#3,004
of 7,841 outputs
Outputs of similar age
#87,757
of 393,707 outputs
Outputs of similar age from Chemical Science
#135
of 461 outputs
Altmetric has tracked 22,883,326 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,841 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 393,707 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 461 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.