| Title |
Patterns and early evolution of organ failure in the intensive care unit and their relation to outcome
|
|---|---|
| Published in |
Critical Care, November 2012
|
| DOI | 10.1186/cc11868 |
| Pubmed ID | |
| Authors |
Yasser Sakr, Suzana M Lobo, Rui P Moreno, Herwig Gerlach, V Marco Ranieri, Argyris Michalopoulos, Jean-Louis Vincent, the SOAP Investigators |
| Abstract |
ABSTRACT: INTRODUCTION: Recognition of patterns of organ failure may be useful in characterizing the clinical course of critically ill patients. We investigated the patterns of early changes in organ dysfunction/failure in intensive care unit (ICU) patients and their relation to outcome. METHODS: Using the database from a large prospective European study, we studied 2,933 patients who had stayed more than 48 hours in the ICU and described patterns of organ failure and their relation to outcome. Patients were divided into three groups: patients without sepsis, patients in whom sepsis was diagnosed within the first 48 hours after ICU admission, and patients in whom sepsis developed more than 48 hours after admission. Organ dysfunction was assessed by using the sequential organ failure assessment (SOFA) score. RESULTS: A total of 2,110 patients (72% of the study population) had organ failure at some point during their ICU stay. Patients who exhibited an improvement in organ function in the first 24 hours after admission to the ICU had lower ICU and hospital mortality rates compared with those who had unchanged or increased SOFA scores (12.4 and 18.4% versus 19.6 and 24.5%, P < 0.05, pairwise). As expected, organ failure was more common in sepsis than in nonsepsis patients. In patients with single-organ failure, in-hospital mortality was greater in sepsis than in nonsepsis patients. However, in patients with multiorgan failure, mortality rates were similar regardless of the presence of sepsis. Irrespective of the presence of sepsis, delta SOFA scores over the first 4 days in the ICU were higher in nonsurvivors than in survivors and decreased significantly over time in survivors. CONCLUSIONS: Early changes in organ function are strongly related to outcome. In patients with single-organ failure, in-hospital mortality was higher in sepsis than in nonsepsis patients. However, in multiorgan failure, mortality rates were not influenced by the presence of sepsis. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 25% |
| United Kingdom | 1 | 25% |
| Australia | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| France | 1 | <1% |
| Brazil | 1 | <1% |
| United Kingdom | 1 | <1% |
| Mexico | 1 | <1% |
| Unknown | 111 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 14 | 12% |
| Student > Ph. D. Student | 13 | 11% |
| Researcher | 11 | 9% |
| Student > Master | 11 | 9% |
| Student > Doctoral Student | 11 | 9% |
| Other | 33 | 28% |
| Unknown | 23 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 63 | 54% |
| Nursing and Health Professions | 6 | 5% |
| Biochemistry, Genetics and Molecular Biology | 5 | 4% |
| Agricultural and Biological Sciences | 4 | 3% |
| Unspecified | 2 | 2% |
| Other | 10 | 9% |
| Unknown | 26 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2012.
All research outputs
#14,388,865
of 25,374,917 outputs
Outputs from Critical Care
#4,749
of 6,554 outputs
Outputs of similar age
#98,201
of 179,074 outputs
Outputs of similar age from Critical Care
#54
of 121 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 121 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.