| Title |
Transcription-coupled repair: an update
|
|---|---|
| Published in |
Archives of Toxicology, August 2016
|
| DOI | 10.1007/s00204-016-1820-x |
| Pubmed ID | |
| Authors |
Graciela Spivak |
| Abstract |
Nucleotide excision repair (NER) is a versatile pathway that removes helix-distorting DNA lesions from the genomes of organisms across the evolutionary scale, from bacteria to humans. The serial steps in NER involve recognition of lesions, adducts or structures that disrupt the DNA double helix, removal of a short oligonucleotide containing the offending lesion, synthesis of a repair patch copying the opposite undamaged strand, and ligation, to restore the DNA to its original form. Transcription-coupled repair (TCR) is a subpathway of NER dedicated to the repair of lesions that, by virtue of their location on the transcribed strands of active genes, encumber elongation by RNA polymerases. In this review, I report on recent findings that contribute to the elucidation of TCR mechanisms in the bacterium Escherichia coli, the yeast Saccharomyces cerevisiae and human cells. I review general models for the biochemical pathways and how and when cells might choose to utilize TCR or other pathways for repair or bypass of transcription-blocking DNA alterations. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 147 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 147 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 21% |
| Student > Master | 21 | 14% |
| Student > Bachelor | 16 | 11% |
| Student > Doctoral Student | 12 | 8% |
| Researcher | 11 | 7% |
| Other | 18 | 12% |
| Unknown | 38 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 57 | 39% |
| Agricultural and Biological Sciences | 25 | 17% |
| Medicine and Dentistry | 6 | 4% |
| Immunology and Microbiology | 5 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
| Other | 10 | 7% |
| Unknown | 41 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 August 2016.
All research outputs
#20,337,788
of 22,883,326 outputs
Outputs from Archives of Toxicology
#2,364
of 2,641 outputs
Outputs of similar age
#300,229
of 343,744 outputs
Outputs of similar age from Archives of Toxicology
#34
of 47 outputs
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