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Human-Specific Histone Methylation Signatures at Transcription Start Sites in Prefrontal Neurons

Overview of attention for article published in PLoS Biology, November 2012
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

news
2 news outlets
blogs
3 blogs
twitter
20 X users
facebook
2 Facebook pages
wikipedia
1 Wikipedia page
googleplus
2 Google+ users
reddit
2 Redditors

Citations

dimensions_citation
115 Dimensions

Readers on

mendeley
205 Mendeley
citeulike
4 CiteULike
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Title
Human-Specific Histone Methylation Signatures at Transcription Start Sites in Prefrontal Neurons
Published in
PLoS Biology, November 2012
DOI 10.1371/journal.pbio.1001427
Pubmed ID
Authors

Hennady P. Shulha, Jessica L. Crisci, Denis Reshetov, Jogender S. Tushir, Iris Cheung, Rahul Bharadwaj, Hsin-Jung Chou, Isaac B. Houston, Cyril J. Peter, Amanda C. Mitchell, Wei-Dong Yao, Richard H. Myers, Jiang-fan Chen, Todd M. Preuss, Evgeny I. Rogaev, Jeffrey D. Jensen, Zhiping Weng, Schahram Akbarian

Abstract

Cognitive abilities and disorders unique to humans are thought to result from adaptively driven changes in brain transcriptomes, but little is known about the role of cis-regulatory changes affecting transcription start sites (TSS). Here, we mapped in human, chimpanzee, and macaque prefrontal cortex the genome-wide distribution of histone H3 trimethylated at lysine 4 (H3K4me3), an epigenetic mark sharply regulated at TSS, and identified 471 sequences with human-specific enrichment or depletion. Among these were 33 loci selectively methylated in neuronal but not non-neuronal chromatin from children and adults, including TSS at DPP10 (2q14.1), CNTN4 and CHL1 (3p26.3), and other neuropsychiatric susceptibility genes. Regulatory sequences at DPP10 and additional loci carried a strong footprint of hominid adaptation, including elevated nucleotide substitution rates and regulatory motifs absent in other primates (including archaic hominins), with evidence for selective pressures during more recent evolution and adaptive fixations in modern populations. Chromosome conformation capture at two neurodevelopmental disease loci, 2q14.1 and 16p11.2, revealed higher order chromatin structures resulting in physical contact of multiple human-specific H3K4me3 peaks spaced 0.5-1 Mb apart, in conjunction with a novel cis-bound antisense RNA linked to Polycomb repressor proteins and downregulated DPP10 expression. Therefore, coordinated epigenetic regulation via newly derived TSS chromatin could play an important role in the emergence of human-specific gene expression networks in brain that contribute to cognitive functions and neurological disease susceptibility in modern day humans.

X Demographics

X Demographics

The data shown below were collected from the profiles of 20 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 205 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 2%
Italy 2 <1%
Switzerland 1 <1%
Netherlands 1 <1%
Germany 1 <1%
United Kingdom 1 <1%
Portugal 1 <1%
Japan 1 <1%
China 1 <1%
Other 0 0%
Unknown 192 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 50 24%
Researcher 41 20%
Student > Master 29 14%
Professor 18 9%
Student > Bachelor 18 9%
Other 36 18%
Unknown 13 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 80 39%
Biochemistry, Genetics and Molecular Biology 37 18%
Neuroscience 20 10%
Medicine and Dentistry 17 8%
Psychology 11 5%
Other 20 10%
Unknown 20 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 52. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2023.
All research outputs
#816,775
of 25,587,485 outputs
Outputs from PLoS Biology
#1,483
of 9,105 outputs
Outputs of similar age
#5,831
of 286,261 outputs
Outputs of similar age from PLoS Biology
#11
of 63 outputs
Altmetric has tracked 25,587,485 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,105 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 47.7. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,261 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.