Title |
Donor-unrestricted T cells in the human CD1 system
|
---|---|
Published in |
Immunogenetics, August 2016
|
DOI | 10.1007/s00251-016-0942-x |
Pubmed ID | |
Authors |
Shouxiong Huang, D. Branch Moody |
Abstract |
The CD1 and MHC systems are specialized for lipid and peptide display, respectively. Here, we review evidence showing how cellular CD1a, CD1b, CD1c, and CD1d proteins capture and display many cellular lipids to T cell receptors (TCRs). Increasing evidence shows that CD1-reactive T cells operate outside two classical immunogenetic concepts derived from the MHC paradigm. First, because CD1 proteins are non-polymorphic in human populations, T cell responses are not restricted to the donor's genetic background. Second, the simplified population genetics of CD1 antigen-presenting molecules can lead to simplified patterns of TCR usage. As contrasted with donor-restricted patterns of MHC-TCR interaction, the donor-unrestricted nature of CD1-TCR interactions raises the prospect that lipid agonists and antagonists of T cells could be developed. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 34 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 24% |
Student > Master | 5 | 15% |
Student > Ph. D. Student | 5 | 15% |
Student > Bachelor | 4 | 12% |
Other | 3 | 9% |
Other | 3 | 9% |
Unknown | 6 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 35% |
Immunology and Microbiology | 9 | 26% |
Biochemistry, Genetics and Molecular Biology | 3 | 9% |
Chemistry | 2 | 6% |
Nursing and Health Professions | 1 | 3% |
Other | 2 | 6% |
Unknown | 5 | 15% |