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Cellular and Molecular Pathology of Age-Related Macular Degeneration: Potential Role for Proteoglycans

Overview of attention for article published in Journal of Ophthalmology, August 2016
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  • High Attention Score compared to outputs of the same age and source (85th percentile)

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2 patents

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31 Dimensions

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Title
Cellular and Molecular Pathology of Age-Related Macular Degeneration: Potential Role for Proteoglycans
Published in
Journal of Ophthalmology, August 2016
DOI 10.1155/2016/2913612
Pubmed ID
Authors

Othman Al Gwairi, Lyna Thach, Wenhua Zheng, Narin Osman, Peter J. Little

Abstract

Age-related macular degeneration (AMD) is a retinal disease evident after the age of 50 that damages the macula in the centre of retina. It leads to a loss of central vision with retained peripheral vision but eventual blindness occurs in many cases. The initiation site of AMD development is Bruch's membrane (BM) where multiple changes occur including the deposition of plasma derived lipids, accumulation of extracellular debris, changes in cell morphology, and viability and the formation of drusen. AMD manifests as early and late stage; the latter involves cell proliferation and neovascularization in wet AMD. Current therapies target the later hyperproliferative and invasive wet stage whilst none target early developmental stages of AMD. In the lipid deposition disease atherosclerosis modified proteoglycans bind and retain apolipoproteins in the artery wall. Chemically modified trapped lipids are immunogenic and can initiate a chronic inflammatory process manifesting as atherosclerotic plaques and subsequent artery blockages, heart attacks, or strokes. As plasma derived lipoprotein deposits are found in BM in early AMD, it is possible that they arise by a similar process within the macula. In this review we consider aspects of the pathological processes underlying AMD with a focus on the potential role of modifications to secreted proteoglycans being a cause and therefore a target for the treatment of early AMD.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 74 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 16 22%
Student > Ph. D. Student 10 14%
Student > Doctoral Student 7 9%
Researcher 6 8%
Student > Master 6 8%
Other 7 9%
Unknown 22 30%
Readers by discipline Count As %
Medicine and Dentistry 20 27%
Biochemistry, Genetics and Molecular Biology 10 14%
Pharmacology, Toxicology and Pharmaceutical Science 4 5%
Neuroscience 4 5%
Agricultural and Biological Sciences 2 3%
Other 9 12%
Unknown 25 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 November 2023.
All research outputs
#7,355,485
of 25,373,627 outputs
Outputs from Journal of Ophthalmology
#152
of 956 outputs
Outputs of similar age
#118,157
of 381,036 outputs
Outputs of similar age from Journal of Ophthalmology
#3
of 21 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 956 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 381,036 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.