| Title |
New cholestane glycosides and sterols from the underground parts of Chamaelirium luteum and their cytotoxic activity
|
|---|---|
| Published in |
Journal of Natural Medicines, November 2012
|
| DOI | 10.1007/s11418-012-0718-z |
| Pubmed ID | |
| Authors |
Akihito Yokosuka, Kenichi Takagi, Yoshihiro Mimaki |
| Abstract |
Six new cholestane glycosides (1, 5, 6, 10, 12, and 13) and two new sterols (9 and 11), along with five known compounds (2-4, 7, and 8), were isolated from the underground parts of Chamaelirium luteum (Liliaceae). The structures of these new compounds were determined by spectroscopic analysis and the results of hydrolytic cleavage. The isolated compounds and aglycones were evaluated for their cytotoxic activity against HL-60 human leukemia cells. Compounds 6a, 10a, 12a, 13, and 13a were cytotoxic to HL-60 cells, with IC50 values of 12.8, 9.8, 15.3, 6.2, and 10.2 µM, respectively. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 9 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Lecturer | 1 | 11% |
| Student > Doctoral Student | 1 | 11% |
| Student > Bachelor | 1 | 11% |
| Student > Ph. D. Student | 1 | 11% |
| Researcher | 1 | 11% |
| Other | 2 | 22% |
| Unknown | 2 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 3 | 33% |
| Chemistry | 2 | 22% |
| Biochemistry, Genetics and Molecular Biology | 1 | 11% |
| Nursing and Health Professions | 1 | 11% |
| Unknown | 2 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 May 2014.
All research outputs
#17,671,894
of 22,687,320 outputs
Outputs from Journal of Natural Medicines
#283
of 530 outputs
Outputs of similar age
#116,423
of 159,110 outputs
Outputs of similar age from Journal of Natural Medicines
#6
of 15 outputs
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