| Title |
Can treatment with statins have a negative influence on the tolerance of mandibular advancement devices?
|
|---|---|
| Published in |
Sleep and Breathing, August 2016
|
| DOI | 10.1007/s11325-016-1399-8 |
| Pubmed ID | |
| Authors |
Mónica González, Emilio Macias-Escalada, Juan Cobo, Maria Pilar Fernández Mondragón, Gerardo Gómez-Moreno, Marian Martínez-Martínez, Felix de Carlos |
| Abstract |
Statins are considered the most effective drugs used in the treatment of dyslipidemias. Some of their adverse effects are related to muscle problems. Myalgias produced by statins appear more often during exercise. Mandibular advancement devices (MAD) force the propulsory and elevatory musculature of the mandible to exercise by making the jaw move forward. The aim of this study is to evaluate the incidence of muscular side effects (referred, spontaneous, or under palpation pain, myofascial pain, mandibular rigidity and fatigue, tension and sensitivity of the masticatory muscles) in a group of patients with a diagnosis of obstructive sleep apnea being treated with MAD. This was a prospective study, involving consecutively 104 patients with a diagnosis of OSAS, and who had begun treatment with a custom made oral device. Muscular side effects were collected by anamnesis (verbal request and questionnaires), psychological status and clinical assessment (manual muscle palpation in the masticatory and cervical muscle groups), before and during MAD treatment. Of the total sample, 22.1 % presented muscular side effects with the oral device. However, in patients taking statins, this percentage was 57.1 %, as opposed to 16.7 % of the non-statins patients (p < 0.001). The risk of suffering muscular alterations during oral device treatment is higher in statin patients (odds ratio 6.67, p = 0.002). Treatment with statins can give rise to the appearance of undesirable side effects among patients being treated with oral devices. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 69 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 17% |
| Student > Master | 9 | 13% |
| Student > Postgraduate | 6 | 8% |
| Student > Bachelor | 6 | 8% |
| Student > Doctoral Student | 5 | 7% |
| Other | 17 | 24% |
| Unknown | 16 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 38% |
| Nursing and Health Professions | 6 | 8% |
| Unspecified | 4 | 6% |
| Sports and Recreations | 3 | 4% |
| Psychology | 3 | 4% |
| Other | 8 | 11% |
| Unknown | 20 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2016.
All research outputs
#20,337,788
of 22,883,326 outputs
Outputs from Sleep and Breathing
#1,011
of 1,382 outputs
Outputs of similar age
#296,993
of 340,306 outputs
Outputs of similar age from Sleep and Breathing
#18
of 26 outputs
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