Title |
Antimicrobial skin peptides and proteins
|
---|---|
Published in |
Cellular and Molecular Life Sciences, January 2006
|
DOI | 10.1007/s00018-005-5364-0 |
Pubmed ID | |
Authors |
J. M. Schröder, J. Harder |
Abstract |
Human skin is permanently exposed to microorganisms, but rarely infected. One reason for this natural resistance might be the existence of a 'chemical barrier' consisting in constitutively and inducibly produced antimicrobial peptides and proteins (AMPs). Many of these AMPs can be induced in vitro by proinflammatory cytokines or bacteria. Apart from being expressed in vivo in inflammatory lesions, some AMPs are also focally expressed in skin in the absence of inflammation. This suggests that non-inflammatory stimuli of endogenous and/or exogenous origin can also stimulate AMP synthesis without inflammation. Such mediators might be ideal 'immune stimulants' to induce only the innate antimicrobial skin effector molecules without causing inflammation. |
Mendeley readers
Geographical breakdown
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---|---|---|
Colombia | 2 | 1% |
India | 2 | 1% |
Austria | 1 | <1% |
Brazil | 1 | <1% |
United Kingdom | 1 | <1% |
Belgium | 1 | <1% |
Thailand | 1 | <1% |
Unknown | 149 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 35 | 22% |
Student > Ph. D. Student | 28 | 18% |
Student > Doctoral Student | 16 | 10% |
Student > Bachelor | 15 | 9% |
Student > Master | 13 | 8% |
Other | 23 | 15% |
Unknown | 28 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 47 | 30% |
Medicine and Dentistry | 28 | 18% |
Biochemistry, Genetics and Molecular Biology | 21 | 13% |
Chemistry | 8 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 4% |
Other | 18 | 11% |
Unknown | 29 | 18% |