Title |
DuCLOX-2/5 inhibition: a promising target for cancer chemoprevention
|
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Published in |
Breast Cancer, August 2016
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DOI | 10.1007/s12282-016-0723-2 |
Pubmed ID | |
Authors |
Swetlana Gautam, Subhadeep Roy, Mohd Nazam Ansari, Abdulaziz S. Saeedan, Shubhini A. Saraf, Gaurav Kaithwas |
Abstract |
Cancer is a leading cause of death and major health concern worldwide. The animal and human studies support the presumption that inflammation directs the cancer initiation and progression. Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) are the key players in the inflammatory cascade contributing towards the angiogenesis, tumor cell invasiveness, and disruption in the pathways of cellular proliferation/apoptosis. Contemporary studies have particularized a promising role of COX-2 and 5-LOX inhibitors in cancer chemoprevention. The present review is a pursuit to define implications of dual COX-2 and 5-LOX (DuCLOX-2/5) inhibition on various aspects of cancer augmentation and chemoprevention. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 4 | 16% |
Professor | 3 | 12% |
Student > Ph. D. Student | 3 | 12% |
Other | 2 | 8% |
Student > Doctoral Student | 1 | 4% |
Other | 3 | 12% |
Unknown | 9 | 36% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 6 | 24% |
Biochemistry, Genetics and Molecular Biology | 5 | 20% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Medicine and Dentistry | 1 | 4% |
Chemistry | 1 | 4% |
Other | 1 | 4% |
Unknown | 10 | 40% |