| Title |
Brain responses to emotional salience and reward in alcohol use disorder
|
|---|---|
| Published in |
Brain Imaging and Behavior, April 2015
|
| DOI | 10.1007/s11682-015-9374-8 |
| Pubmed ID | |
| Authors |
L. Alba-Ferrara, E. M. Müller-Oehring, E. V. Sullivan, A. Pfefferbaum, T. Schulte |
| Abstract |
Heightened neural responsiveness of alcoholics to alcohol cues and social emotion may impede sobriety. To test mesocorticolimbic network responsivity, 10 (8 men) alcohol use disorder (AUD) patients sober for 3 weeks to 10 months and 11 (8 men) controls underwent fMRI whilst viewing pictures of alcohol and non-alcohol beverages and of emotional faces (happy, sad, angry). AUD and controls showed similarities in mesocorticolimbic activity: both groups activated fusiform for emotional faces and hippocampal and pallidum regions during alcohol picture processing. In AUD, less fusiform activity to emotional faces and more pallidum activity to alcohol pictures were associated with longer sobriety. Using graph theory-based network efficiency measures to specify the role of the mesocorticolimbic network nodes for emotion and reward in sober AUD revealed that the left hippocampus was less efficiently connected with the other task-activated network regions in AUD than controls when viewing emotional faces, while the pallidum was more efficiently connected when viewing alcohol beverages. Together our findings identified lower occipito-temporal sensitivity to emotional faces and enhanced striatal sensitivity to alcohol stimuli in AUD than controls. Considering the role of the striatum in encoding reward, its activation enhancement with longer sobriety may reflect adaptive neural changes in the first year of drinking cessation and mesocorticolimbic system vulnerability for encoding emotional salience and reward potentially affecting executive control ability and relapse propensity during abstinence. |
Mendeley readers
The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 1% |
| Unknown | 92 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 16% |
| Student > Ph. D. Student | 14 | 15% |
| Student > Master | 11 | 12% |
| Student > Bachelor | 8 | 9% |
| Other | 7 | 8% |
| Other | 16 | 17% |
| Unknown | 22 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 23 | 25% |
| Neuroscience | 19 | 20% |
| Medicine and Dentistry | 10 | 11% |
| Nursing and Health Professions | 2 | 2% |
| Computer Science | 2 | 2% |
| Other | 8 | 9% |
| Unknown | 29 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2021.
All research outputs
#6,442,064
of 22,883,326 outputs
Outputs from Brain Imaging and Behavior
#358
of 1,155 outputs
Outputs of similar age
#76,295
of 264,051 outputs
Outputs of similar age from Brain Imaging and Behavior
#7
of 36 outputs
Altmetric has tracked 22,883,326 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 1,155 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,051 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.