| Title |
CD26 and Asthma: a Comprehensive Review
|
|---|---|
| Published in |
Clinical Reviews in Allergy & Immunology, August 2016
|
| DOI | 10.1007/s12016-016-8578-z |
| Pubmed ID | |
| Authors |
Juan J. Nieto-Fontarigo, Francisco J. González-Barcala, Esther San José, Pilar Arias, Montserrat Nogueira, Francisco J. Salgado |
| Abstract |
Asthma is a heterogeneous and chronic inflammatory family of disorders of the airways with increasing prevalence that results in recurrent and reversible bronchial obstruction and expiratory airflow limitation. These diseases arise from the interaction between environmental and genetic factors, which collaborate to cause increased susceptibility and severity. Many asthma susceptibility genes are linked to the immune system or encode enzymes like metalloproteases (e.g., ADAM-33) or serine proteases. The S9 family of serine proteases (prolyl oligopeptidases) is capable to process peptide bonds adjacent to proline, a kind of cleavage-resistant peptide bonds present in many growth factors, chemokines or cytokines that are important for asthma. Curiously, two serine proteases within the S9 family encoded by genes located on chromosome 2 appear to have a role in asthma: CD26/dipeptidyl peptidase 4 (DPP4) and DPP10. The aim of this review is to summarize the current knowledge about CD26 and to provide a structured overview of the numerous functions and implications that this versatile enzyme could have in this disease, especially after the detection of some secondary effects (e.g., viral nasopharyngitis) in type II diabetes mellitus patients (a subset with a certain risk of developing obesity-related asthma) upon CD26 inhibitory therapy. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 20% |
| Mexico | 1 | 20% |
| Canada | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Scientists | 2 | 40% |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 50 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 16% |
| Student > Bachelor | 5 | 10% |
| Researcher | 5 | 10% |
| Student > Ph. D. Student | 5 | 10% |
| Student > Doctoral Student | 4 | 8% |
| Other | 9 | 18% |
| Unknown | 14 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 30% |
| Biochemistry, Genetics and Molecular Biology | 3 | 6% |
| Nursing and Health Professions | 3 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
| Agricultural and Biological Sciences | 3 | 6% |
| Other | 7 | 14% |
| Unknown | 16 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2019.
All research outputs
#13,722,312
of 23,975,976 outputs
Outputs from Clinical Reviews in Allergy & Immunology
#437
of 690 outputs
Outputs of similar age
#177,977
of 345,087 outputs
Outputs of similar age from Clinical Reviews in Allergy & Immunology
#6
of 12 outputs
Altmetric has tracked 23,975,976 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 690 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.8. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
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We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.