| Title |
An integrated lab-on-a-chip-based electrochemical biosensor for rapid and sensitive detection of cancer biomarkers
|
|---|---|
| Published in |
Analytical & Bioanalytical Chemistry, August 2016
|
| DOI | 10.1007/s00216-016-9879-z |
| Pubmed ID | |
| Authors |
Yildiz Uludag, Fehmi Narter, Erkin Sağlam, Güzin Köktürk, M. Yağmur Gök, Mete Akgün, Serkan Barut, Sinan Budak |
| Abstract |
Recent advances in the area of biosensor technology and microfluidic applications have enabled the miniaturisation of the sensing platforms. Here we describe a new integrated and fully automated lab-on-a-chip-based biosensor device prototype (MiSens) that has potential to be used for point-of-care cancer biomarker testing. The key features of the device include a new biochip, a device integrated microfluidic system and real-time amperometric measurements during the flow of enzyme substrate. For ease of use, a new plug and play type sensor chip docking station has been designed. This system allows the formation of an ∼7 μL capacity flow cell on the electrode array with the necessary microfluidic and electronic connections with one move of a handle. As a case study, the developed prototype has been utilised for the detection of prostate-specific antigen (PSA) level in serum that is routinely used as a biomarker for the diagnosis of prostate cancer. The patient samples from a nearby hospital have been collected and tested using the MiSens device, and the results have been compared to the hospital results. The obtained results indicate the potential of the MiSens device as a useful tool for point-of-care testing. Graphical abstract Microfluidics integrated and automated electrochemical biosensor device "MiSens" has been designed and fabricated by a multidisciplinary team and utilised to detect PSA from clinical samples. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 71 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 23% |
| Student > Master | 11 | 15% |
| Student > Bachelor | 10 | 14% |
| Researcher | 7 | 10% |
| Student > Doctoral Student | 5 | 7% |
| Other | 3 | 4% |
| Unknown | 19 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 15 | 21% |
| Engineering | 12 | 17% |
| Biochemistry, Genetics and Molecular Biology | 6 | 8% |
| Agricultural and Biological Sciences | 3 | 4% |
| Arts and Humanities | 2 | 3% |
| Other | 9 | 13% |
| Unknown | 24 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 October 2016.
All research outputs
#15,982,793
of 25,373,627 outputs
Outputs from Analytical & Bioanalytical Chemistry
#4,917
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Outputs of similar age
#207,954
of 351,391 outputs
Outputs of similar age from Analytical & Bioanalytical Chemistry
#50
of 182 outputs
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So far Altmetric has tracked 9,618 research outputs from this source. They receive a mean Attention Score of 3.1. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
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We're also able to compare this research output to 182 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.