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X Demographics
Mendeley readers
Attention Score in Context
| Title |
APOE E4 Carriers Show Prospective Memory Enhancement Under Nicotine, and Evidence for Specialisation Within Medial BA10
|
|---|---|
| Published in |
Neuropsychopharmacology, November 2012
|
| DOI | 10.1038/npp.2012.230 |
| Pubmed ID | |
| Authors |
Simon Evans, Marcus A Gray, Nicholas G Dowell, Naji Tabet, Paul S Tofts, Sarah L King, Jennifer M Rusted |
| Abstract |
There is evidence to suggest that the APOE ɛ4 allele (which confers an increased risk of developing dementia) might be associated with cognitive advantages earlier in life. Further, nicotine might selectively benefit ɛ4 carriers. We used fMRI to explore performance on a prospective memory (PM) task in young adults (age 18-30) with and without nicotine using a within-subjects design. Participants performed an ongoing task while retaining a PM instruction to respond to specific stimuli embedded in the task. Nicotine effects varied according to APOE status. Reaction times to the PM cue were improved under nicotine in ɛ4 carriers, but not in ɛ3 carriers. In an event-related analysis, extrastriate responses to PM trials were enhanced by nicotine only in ɛ4 carriers. These differences in early visual processing may contribute to the behavioral findings. Activity in medial BA10 (previously implicated in PM) differentiated ɛ4 from ɛ3 carriers. One BA10 subregion showed greater deactivation in ɛ4 carriers during PM trials. Activity in other BA10 subregions was modulated by PM reaction time, pointing to region-specific effects within medial BA10. In addition, activity in right hippocampal formation was only seen in ɛ4 carriers receiving nicotine. These results demonstrate that cognitive enhancement by nicotine can selectively benefit APOE ɛ4 carriers, and point to genotype-specific differences in neural activity during PM. In addition, these results show that the role of medial BA10 in PM likely involves varying contributions from functionally specific subregions. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 33% |
| Switzerland | 1 | 17% |
| Japan | 1 | 17% |
| Unknown | 2 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 3% |
| France | 1 | 2% |
| Unknown | 63 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 21% |
| Researcher | 13 | 20% |
| Student > Master | 4 | 6% |
| Professor | 3 | 5% |
| Student > Bachelor | 3 | 5% |
| Other | 10 | 15% |
| Unknown | 19 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 16 | 24% |
| Neuroscience | 9 | 14% |
| Medicine and Dentistry | 8 | 12% |
| Agricultural and Biological Sciences | 4 | 6% |
| Mathematics | 1 | 2% |
| Other | 5 | 8% |
| Unknown | 23 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 November 2023.
All research outputs
#6,144,207
of 24,796,076 outputs
Outputs from Neuropsychopharmacology
#2,374
of 4,384 outputs
Outputs of similar age
#43,330
of 188,243 outputs
Outputs of similar age from Neuropsychopharmacology
#18
of 54 outputs
Altmetric has tracked 24,796,076 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,384 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 188,243 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.