| Title |
Alzheimer’s disease and gut microbiota
|
|---|---|
| Published in |
Science China Life Sciences, August 2016
|
| DOI | 10.1007/s11427-016-5083-9 |
| Pubmed ID | |
| Authors |
Xu Hu, Tao Wang, Feng Jin |
| Abstract |
Alzheimer's disease (AD) is a most common neurodegenerative disorder, which associates with impaired cognition. Gut microbiota can modulate host brain function and behavior via microbiota-gut-brain axis, including cognitive behavior. Germ-free animals, antibiotics, probiotics intervention and diet can induce alterations of gut microbiota and gut physiology and also host cognitive behavior, increasing or decreasing risks of AD. The increased permeability of intestine and blood-brain barrier induced by gut microbiota disturbance will increase the incidence of neurodegeneration disorders. Gut microbial metabolites and their effects on host neurochemical changes may increase or decrease the risk of AD. Pathogenic microbes infection will also increase the risk of AD, and meanwhile, the onset of AD support the "hygiene hypothesis". All the results suggest that AD may begin in the gut, and is closely related to the imbalance of gut microbiota. Modulation of gut microbiota through personalized diet or beneficial microbiota intervention will probably become a new treatment for AD. |
X Demographics
The data shown below were collected from the profiles of 44 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 12 | 27% |
| United States | 9 | 20% |
| Australia | 3 | 7% |
| Venezuela, Bolivarian Republic of | 1 | 2% |
| Mexico | 1 | 2% |
| Unknown | 18 | 41% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 33 | 75% |
| Practitioners (doctors, other healthcare professionals) | 9 | 20% |
| Scientists | 2 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 678 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Netherlands | 1 | <1% |
| Unknown | 676 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 121 | 18% |
| Student > Master | 87 | 13% |
| Researcher | 63 | 9% |
| Student > Ph. D. Student | 54 | 8% |
| Student > Doctoral Student | 30 | 4% |
| Other | 109 | 16% |
| Unknown | 214 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 91 | 13% |
| Medicine and Dentistry | 65 | 10% |
| Neuroscience | 64 | 9% |
| Agricultural and Biological Sciences | 59 | 9% |
| Nursing and Health Professions | 32 | 5% |
| Other | 125 | 18% |
| Unknown | 242 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 77. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 March 2022.
All research outputs
#487,676
of 23,493,900 outputs
Outputs from Science China Life Sciences
#13
of 1,039 outputs
Outputs of similar age
#10,431
of 340,711 outputs
Outputs of similar age from Science China Life Sciences
#2
of 22 outputs
Altmetric has tracked 23,493,900 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,039 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.7. This one has done particularly well, scoring higher than 98% of its peers.
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We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.