| Title |
How important is vitamin D in preventing infections?
|
|---|---|
| Published in |
Osteoporosis International, November 2012
|
| DOI | 10.1007/s00198-012-2204-6 |
| Pubmed ID | |
| Authors |
P. O. Lang, N. Samaras, D. Samaras, R. Aspinall |
| Abstract |
Interaction with the immune system is one of the most recently established nonclassic effects of vitamin D (VitD). For many years, this was considered to be limited to granulomatous diseases in which synthesis of active 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) or calcitriol is known to be increased. However, recent reports have supported a role for 1,25(OH)2D3 in promoting normal function of the innate and adaptive immune systems. Crucially, these effects seem to be mediated not only by the endocrine function of circulating calcitriol but also via paracrine (i.e., refers to effects to adjacent or nearby cells) and/or intracrine activity (i.e., refers to a hormone acting inside a cell) of 1,25(OH)2D3 from its precursor 25(OH)D3, the main circulating metabolite of VitD. The ability of this vitamin to influence human immune responsiveness seems to be highly dependent on the 25(OH)D3 status of individuals and may lead to aberrant response to infection or even to autoimmunity in those who are lacking VitD. The potential health significance of this has been underlined by increasing awareness of impaired status in populations across the globe. This review will examine the current understanding of how VitD status may modulate the responsiveness of the human immune system. Furthermore, we discuss how it may play a role in host resistance to common pathogens and how effective is its supplementation for treatment or prevention of infectious diseases in humans. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 1% |
| Colombia | 1 | 1% |
| Turkey | 1 | 1% |
| South Africa | 1 | 1% |
| United Kingdom | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 89 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 18 | 19% |
| Researcher | 11 | 12% |
| Student > Bachelor | 11 | 12% |
| Student > Ph. D. Student | 7 | 7% |
| Student > Postgraduate | 6 | 6% |
| Other | 20 | 21% |
| Unknown | 22 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 28% |
| Agricultural and Biological Sciences | 15 | 16% |
| Immunology and Microbiology | 6 | 6% |
| Nursing and Health Professions | 4 | 4% |
| Biochemistry, Genetics and Molecular Biology | 4 | 4% |
| Other | 13 | 14% |
| Unknown | 26 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 August 2015.
All research outputs
#15,391,792
of 24,397,600 outputs
Outputs from Osteoporosis International
#2,301
of 3,795 outputs
Outputs of similar age
#174,131
of 284,511 outputs
Outputs of similar age from Osteoporosis International
#23
of 32 outputs
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