| Title |
Mechanisms and risk factors for type 1 food allergies: the role of gastric digestion
|
|---|---|
| Published in |
Wiener Medizinische Wochenschrift, November 2012
|
| DOI | 10.1007/s10354-012-0154-4 |
| Pubmed ID | |
| Authors |
Susanne C. Diesner, Isabella Pali-Schöll, Erika Jensen-Jarolim, Eva Untersmayr |
| Abstract |
True food allergens are considered as digestion stable proteins, which are absorbed through the gastrointestinal epithelium in an intact form leading to sensitization and causing systemic symptoms. According to classifications, allergens, which are digestion-labile, cause local symptoms by their cross-reactivity towards inhalative allergens. Our recent studies revealed that digestion labile allergens can also have sensitizing capacity if gastric digestion is hindered. The increase of gastric pH via acid-suppression by proton pump inhibitors, sucralfate or antacids, interferes with protein digestion, and leads to sensitization and allergic reaction in mouse models as well as in human patients. Furthermore, the inhibition of digestion increases the risk for anaphylactic responses in sensitized individuals.Even though also other factors, such as sphingolipid metabolites, are associated with the development of food allergies, it is without any doubt that the stomach has an important gate keeping function against food allergies. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor | 1 | 25% |
| Student > Bachelor | 1 | 25% |
| Researcher | 1 | 25% |
| Student > Doctoral Student | 1 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 25% |
| Immunology and Microbiology | 1 | 25% |
| Social Sciences | 1 | 25% |
| Medicine and Dentistry | 1 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2020.
All research outputs
#2,482,971
of 23,849,058 outputs
Outputs from Wiener Medizinische Wochenschrift
#38
of 436 outputs
Outputs of similar age
#24,035
of 281,167 outputs
Outputs of similar age from Wiener Medizinische Wochenschrift
#4
of 10 outputs
Altmetric has tracked 23,849,058 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 436 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done particularly well, scoring higher than 91% of its peers.
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