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Mendeley readers
Attention Score in Context
| Title |
The DIAN‐TU Next Generation Alzheimer's prevention trial: Adaptive design and disease progression model
|
|---|---|
| Published in |
Alzheimer's & Dementia: the Journal of the Alzheimer's Association, August 2016
|
| DOI | 10.1016/j.jalz.2016.07.005 |
| Pubmed ID | |
| Authors |
Randall J. Bateman, Tammie L. Benzinger, Scott Berry, David B. Clifford, Cynthia Duggan, Anne M. Fagan, Kathleen Fanning, Martin R. Farlow, Jason Hassenstab, Eric M. McDade, Susan Mills, Katrina Paumier, Melanie Quintana, Stephen P. Salloway, Anna Santacruz, Lon S. Schneider, Guoqiao Wang, Chengjie Xiong, the DIAN‐TU Pharma Consortium for the Dominantly Inherited Alzheimer Network |
| Abstract |
The Dominantly Inherited Alzheimer Network Trial Unit (DIAN-TU) is an adaptive platform trial testing multiple drugs to slow or prevent the progression of Alzheimer's disease in autosomal dominant Alzheimer's disease (ADAD) families. With completion of enrollment of the first two drug arms, the DIAN-TU now plans to add new drugs to the platform, designated as the Next Generation (NexGen) prevention trial. In collaboration with ADAD families, philanthropic organizations, academic leaders, the DIAN-TU Pharma Consortium, the National Institutes of Health, and regulatory colleagues, the DIAN-TU developed innovative clinical study designs for the DIAN-TU NexGen prevention trial. Our expanded trial toolbox consists of a disease progression model for ADAD, primary end point DIAN-TU cognitive performance composite, biomarker development, self-administered cognitive assessments, adaptive dose adjustments, and blinded data collection through the last participant completion. These steps represent elements to improve efficacy of the adaptive platform trial and a continued effort to optimize prevention and treatment trials in ADAD. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 25% |
| United Kingdom | 1 | 13% |
| Unknown | 5 | 63% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 88% |
| Scientists | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 269 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 269 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 53 | 20% |
| Student > Ph. D. Student | 42 | 16% |
| Student > Master | 25 | 9% |
| Student > Bachelor | 24 | 9% |
| Other | 18 | 7% |
| Other | 42 | 16% |
| Unknown | 65 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 52 | 19% |
| Neuroscience | 36 | 13% |
| Biochemistry, Genetics and Molecular Biology | 18 | 7% |
| Psychology | 12 | 4% |
| Agricultural and Biological Sciences | 11 | 4% |
| Other | 63 | 23% |
| Unknown | 77 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2023.
All research outputs
#1,578,608
of 25,394,764 outputs
Outputs from Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#734
of 4,063 outputs
Outputs of similar age
#28,000
of 349,186 outputs
Outputs of similar age from Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#11
of 38 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,063 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 32.3. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 349,186 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.