| Title |
Effect of a ketogenic meal on cognitive function in elderly adults: potential for cognitive enhancement
|
|---|---|
| Published in |
Psychopharmacology, August 2016
|
| DOI | 10.1007/s00213-016-4414-7 |
| Pubmed ID | |
| Authors |
Miho Ota, Junko Matsuo, Ikki Ishida, Kotaro Hattori, Toshiya Teraishi, Hidekazu Tonouchi, Kinya Ashida, Takeshi Takahashi, Hiroshi Kunugi |
| Abstract |
Glucose is the principal energy substrate for the brain, although ketone bodies are an effective alternative. Evidence suggests that elevation of plasma ketone body levels through oral intake of medium chain triglycerides (MCTs) may improve cognitive function. We tried to examine the possible effects of a ketogenic meal serving on cognition in elderly non-demented subjects. Subjects were 19 non-demented elderly adults over 60 years old (13 females; mean age: 66.1 ± 2.9 years) who underwent neurocognitive tests 90 and 180 min after oral intake of a ketogenic meal (Ketonformula®) containing 20 g of MCTs and an isocaloric placebo meal without MCTs on separate days. Elevation of plasma ketone concentration after intake of a single ketogenic meal containing 20 g of MCTs was confirmed (all p < 0.001). As for cognition, improvements were observed in the digit span test, Trail-Making Test B, and the global score (Z = -2.4, p = 0.017) following the ketogenic meal and the change in the executive functioning score was positively correlated with that of the plasma β-hydroxybutyrate level. The cognition-enhancing effect was observed predominantly for individuals who had a relatively low global score at baseline (Z = -2.8, p = 0.005), compared to individuals with a high global score (Z = -0.7, p = 0.51). Plasma levels of ketone bodies were successfully increased after intake of the ketogenic meal. The ketogenic meal was suggested to have positive effects on working memory, visual attention, and task switching in non-demented elderly. |
X Demographics
The data shown below were collected from the profiles of 23 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 22% |
| United Kingdom | 3 | 13% |
| Sweden | 2 | 9% |
| Brazil | 2 | 9% |
| Ecuador | 1 | 4% |
| Canada | 1 | 4% |
| South Africa | 1 | 4% |
| Australia | 1 | 4% |
| Unknown | 7 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 18 | 78% |
| Scientists | 4 | 17% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 158 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 158 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 28 | 18% |
| Student > Master | 27 | 17% |
| Researcher | 17 | 11% |
| Student > Ph. D. Student | 13 | 8% |
| Student > Postgraduate | 9 | 6% |
| Other | 26 | 16% |
| Unknown | 38 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 26 | 16% |
| Neuroscience | 25 | 16% |
| Agricultural and Biological Sciences | 12 | 8% |
| Nursing and Health Professions | 11 | 7% |
| Biochemistry, Genetics and Molecular Biology | 9 | 6% |
| Other | 30 | 19% |
| Unknown | 45 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 39. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 October 2023.
All research outputs
#1,065,959
of 25,758,695 outputs
Outputs from Psychopharmacology
#265
of 5,357 outputs
Outputs of similar age
#19,335
of 350,921 outputs
Outputs of similar age from Psychopharmacology
#8
of 57 outputs
Altmetric has tracked 25,758,695 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,357 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.1. This one has done particularly well, scoring higher than 95% of its peers.
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