Title |
Targeting Th17 Effector Cytokines for the Treatment of Autoimmune Diseases
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Published in |
Archivum Immunologiae et Therapiae Experimentalis, September 2015
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DOI | 10.1007/s00005-015-0362-x |
Pubmed ID | |
Authors |
Tetsuya Yamagata, Jill Skepner, Jianfei Yang |
Abstract |
Interleukin (IL)-17-producing T cells, especially T helper (Th)17 cells, play a critical role in the pathogenesis of a variety of autoimmune inflammatory diseases. The pathogenic function of Th17 cells results from their production of Th17 effector cytokines, namely IL-17 (or IL-17A), IL-17F, IL-22 and IL-26. The importance of IL-17 has been demonstrated by antibody neutralization studies in both animal models of autoimmune diseases as well as in human clinical trials. This review highlights the current knowledge of the clinical aspects of the Th17 cytokines as well as therapeutic antibodies against IL-17, IL-17F, IL-17 receptor, IL-22, IL-26 and granulocyte macrophage colony-stimulating factor for the future treatment of autoimmune inflammatory diseases. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 35 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 20% |
Student > Doctoral Student | 5 | 14% |
Researcher | 5 | 14% |
Student > Master | 3 | 9% |
Student > Bachelor | 2 | 6% |
Other | 5 | 14% |
Unknown | 8 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 26% |
Immunology and Microbiology | 8 | 23% |
Biochemistry, Genetics and Molecular Biology | 3 | 9% |
Agricultural and Biological Sciences | 2 | 6% |
Veterinary Science and Veterinary Medicine | 1 | 3% |
Other | 5 | 14% |
Unknown | 7 | 20% |