Title |
Single-use disposable technologies for biopharmaceutical manufacturing
|
---|---|
Published in |
Trends in Biotechnology, November 2012
|
DOI | 10.1016/j.tibtech.2012.10.004 |
Pubmed ID | |
Authors |
Abhinav A. Shukla, Uwe Gottschalk |
Abstract |
The manufacture of protein biopharmaceuticals is conducted under current good manufacturing practice (cGMP) and involves multiple unit operations for upstream production and downstream purification. Until recently, production facilities relied on the use of relatively inflexible, hard-piped equipment including large stainless steel bioreactors and tanks to hold product intermediates and buffers. However, there is an increasing trend towards the adoption of single-use technologies across the manufacturing process. Technical advances have now made an end-to-end single-use manufacturing facility possible, but several aspects of single-use technology require further improvement and are continually evolving. This article provides a perspective on the current state-of-the-art in single-use technologies and highlights trends that will improve performance and increase the market penetration of disposable manufacturing in the future. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Nepal | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 3 | <1% |
United States | 2 | <1% |
Switzerland | 1 | <1% |
France | 1 | <1% |
Brazil | 1 | <1% |
India | 1 | <1% |
Malaysia | 1 | <1% |
Mexico | 1 | <1% |
Canada | 1 | <1% |
Other | 2 | <1% |
Unknown | 595 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 130 | 21% |
Student > Bachelor | 124 | 20% |
Student > Ph. D. Student | 86 | 14% |
Researcher | 56 | 9% |
Other | 25 | 4% |
Other | 55 | 9% |
Unknown | 133 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 100 | 16% |
Engineering | 95 | 16% |
Biochemistry, Genetics and Molecular Biology | 92 | 15% |
Chemical Engineering | 66 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 35 | 6% |
Other | 70 | 11% |
Unknown | 151 | 25% |