| Title |
Stress-Induced Immune Dysregulation: Implications for Wound Healing, Infectious Disease and Cancer
|
|---|---|
| Published in |
Journal of Neuroimmune Pharmacology, August 2006
|
| DOI | 10.1007/s11481-006-9036-0 |
| Pubmed ID | |
| Authors |
Jonathan P. Godbout, Ronald Glaser |
| Abstract |
The communication between the central nervous system and the immune system occurs via a complex network of bidirectional signals linking the nervous, endocrine and immune systems. The field of psychoneuroimmunology (PNI) has provided new insights to help understand the pathophysiological processes that are linked to the immune system. Work in this field has established that psychological stress disrupts the functional interaction between the nervous and immune systems. Stress-induced immune dysregulation has been shown to be significant enough to result in health consequences, including reducing the immune response to vaccines, slowing wound healing, reactivating latent herpesviruses, such as Epstein-Barr virus (EBV), and enhancing the risk for more severe infectious disease. Chronic stress/depression can increase the peripheral production of proinflammatory cytokines, such as interleukin (IL)-6. High serum levels of IL-6 have been linked to risks for several conditions, such as cardiovascular disease, type 2 diabetes, mental health complications, and some cancers. This overview will discuss the evidence that psychological stress promotes immune dysfunction that negatively impacts human health. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Venezuela, Bolivarian Republic of | 2 | 29% |
| Ireland | 1 | 14% |
| Unknown | 4 | 57% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 86% |
| Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 481 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 1% |
| Italy | 3 | <1% |
| India | 2 | <1% |
| United Kingdom | 2 | <1% |
| Turkey | 1 | <1% |
| Brazil | 1 | <1% |
| Hungary | 1 | <1% |
| Switzerland | 1 | <1% |
| Mexico | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 462 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 72 | 15% |
| Student > Bachelor | 70 | 15% |
| Student > Ph. D. Student | 65 | 14% |
| Researcher | 59 | 12% |
| Student > Postgraduate | 25 | 5% |
| Other | 73 | 15% |
| Unknown | 117 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 93 | 19% |
| Agricultural and Biological Sciences | 61 | 13% |
| Psychology | 58 | 12% |
| Biochemistry, Genetics and Molecular Biology | 27 | 6% |
| Nursing and Health Professions | 15 | 3% |
| Other | 94 | 20% |
| Unknown | 133 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2022.
All research outputs
#1,541,480
of 25,081,285 outputs
Outputs from Journal of Neuroimmune Pharmacology
#44
of 599 outputs
Outputs of similar age
#2,699
of 83,090 outputs
Outputs of similar age from Journal of Neuroimmune Pharmacology
#2
of 8 outputs
Altmetric has tracked 25,081,285 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 599 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.8. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 83,090 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.