Title |
Long-term Treatment of Teicoplanin for Methicillin-resistant Staphylococcus aureus Sternal Osteomyelitis with Renal Impairment: A Case of High Teicoplanin Trough Levels Maintained by Therapeutic Drug Monitoring
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Published in |
Yakugaku Zasshi = Journal of Pharmaceutical Society of Japan, September 2016
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DOI | 10.1248/yakushi.15-00296 |
Pubmed ID | |
Authors |
潮平 英郎, 仲松 正司, 喜瀬 勇也, 比嘉 太, 健山 正男, 外間 惟夫, 国吉 幸男, 植田 真一郎, 中村 克徳, 藤田 次郎 |
Abstract |
Teicoplanin, a glycopeptide antibiotic for methicillin-resistant Staphylococcus aureus, is recommended for therapeutic drug monitoring during treatment. Maintaining a high trough range of teicoplanin is also recommended for severe infectious disease. However, the optimal dose and interval of treatment for severe renal impairment is unknown. We report a 79-year-old man who received long-term teicoplanin treatment for methicillin-resistant Staphylococcus aureus bacteremia due to postoperative sternal osteomyelitis with renal impairment. Plasma teicoplanin trough levels were maintained at a high range (20-30 μg/mL). Although the patient required long-term teicoplanin treatment, a further decline in renal function was not observed, and blood culture remained negative after the start of treatment. Teicoplanin treatment that is maintained at a high trough level by therapeutic drug monitoring might be beneficial for severe methicillin-resistant Staphylococcus aureus infection accompanied by renal impairment. |
X Demographics
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
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Country | Count | As % |
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Unknown | 19 | 100% |
Demographic breakdown
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Student > Master | 5 | 26% |
Other | 3 | 16% |
Student > Postgraduate | 2 | 11% |
Student > Ph. D. Student | 1 | 5% |
Researcher | 1 | 5% |
Other | 1 | 5% |
Unknown | 6 | 32% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 6 | 32% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 16% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Psychology | 1 | 5% |
Agricultural and Biological Sciences | 1 | 5% |
Other | 0 | 0% |
Unknown | 7 | 37% |