| Title |
Tart cherry supplementation improves working memory, hippocampal inflammation, and autophagy in aged rats
|
|---|---|
| Published in |
GeroScience, August 2016
|
| DOI | 10.1007/s11357-016-9945-7 |
| Pubmed ID | |
| Authors |
Nopporn Thangthaeng, Shibu M. Poulose, Stacey M. Gomes, Marshall G. Miller, Donna F. Bielinski, Barbara Shukitt-Hale |
| Abstract |
High consumption of fruits and vegetables has been associated with reduced risk of debilitating diseases and improved cognition in aged populations. These beneficial effects have been attributed to the phytochemicals found in fruits and vegetables, which have previously been shown to be anti-inflammatory and modulate autophagy. Tart cherries contain a variety of potentially beneficial phytochemicals; however, little research has been done to investigate the effects of tart cherry on the aging brain. Therefore, the purpose of this study was to determine if tart cherry supplementation can improve cognitive and motor function of aged rats via modulation of inflammation and autophagy in the brain. Thirty 19-month-old male Fischer 344 rats were weight-matched and assigned to receive either a control diet or a diet supplemented with 2 % Montmorency tart cherry. After 6 weeks on the diet, rats were given a battery of behavioral tests to assess for strength, stamina, balance, and coordination, as well as learning and working memory. Although no significant effects were observed on tests of motor performance, tart cherry improved working memory of aged rats. Following behavioral testing, the hippocampus was collected for western/densitometric analysis of inflammatory (GFAP, NOX-2, and COX-2) and autophagy (phosphorylated mTOR, Beclin 1, and p62/SQSTM) markers. Tart cherry supplementation significantly reduced inflammatory markers and improved autophagy function. Daily consumption of tart cherry reduced age-associated inflammation and promoted protein/cellular homeostasis in the hippocampus, along with improvements in working memory. Therefore, addition of tart cherry to the diet may promote healthy aging and/or delay the onset of neurodegenerative diseases. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 67% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 69 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 13% |
| Student > Master | 7 | 10% |
| Researcher | 6 | 9% |
| Student > Doctoral Student | 6 | 9% |
| Student > Bachelor | 6 | 9% |
| Other | 12 | 17% |
| Unknown | 23 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 13% |
| Medicine and Dentistry | 6 | 9% |
| Neuroscience | 6 | 9% |
| Psychology | 5 | 7% |
| Biochemistry, Genetics and Molecular Biology | 4 | 6% |
| Other | 11 | 16% |
| Unknown | 28 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 March 2023.
All research outputs
#3,236,978
of 25,460,914 outputs
Outputs from GeroScience
#420
of 1,605 outputs
Outputs of similar age
#52,782
of 348,334 outputs
Outputs of similar age from GeroScience
#3
of 17 outputs
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We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.