Title |
Antiepileptic drugs and bone metabolism
|
---|---|
Published in |
Nutrition & Metabolism, September 2006
|
DOI | 10.1186/1743-7075-3-36 |
Pubmed ID | |
Authors |
Helen A Valsamis, Surender K Arora, Barbara Labban, Samy I McFarlane |
Abstract |
Anti-epileptic medications encompass a wide range of drugs including anticonvulsants, benzodiazepines, enzyme inducers or inhibitors, with a variety effects, including induction of cytochrome P450 and other enzyme, which may lead to catabolism of vitamin D and hypocalcemia and other effects that may significantly effect the risk for low bone mass and fractures. With the current estimates of 50 million people worldwide with epilepsy together with the rapid increase in utilization of these medications for other indications, bone disease associated with the use of anti-epileptic medications is emerging as a serious health threat for millions of people. Nevertheless, it usually goes unrecognized and untreated. In this review we discuss the pathophysiologic mechanisms of bone disease associated with anti-epileptic use, including effect of anti-epileptic agents on bone turnover and fracture risk, highlighting various strategies for prevention of bone loss and associated fractures a rapidly increasing vulnerable population. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Colombia | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 109 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 18 | 16% |
Student > Master | 16 | 14% |
Researcher | 11 | 10% |
Student > Ph. D. Student | 10 | 9% |
Other | 8 | 7% |
Other | 25 | 22% |
Unknown | 24 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 42 | 38% |
Nursing and Health Professions | 12 | 11% |
Agricultural and Biological Sciences | 10 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 7% |
Neuroscience | 4 | 4% |
Other | 11 | 10% |
Unknown | 25 | 22% |