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Mendeley readers
Attention Score in Context
| Title |
Blood meal induced microRNA regulates development and immune associated genes in the Dengue mosquito vector, Aedes aegypti
|
|---|---|
| Published in |
Insect Biochemistry & Molecular Biology, November 2012
|
| DOI | 10.1016/j.ibmb.2012.11.005 |
| Pubmed ID | |
| Authors |
Mazhar Hussain, Thomas Walker, Scott L. O'Neill, Sassan Asgari |
| Abstract |
Aedes aegypti is a blood-feeding mosquito that transmits human pathogens such as Dengue virus, Yellow Fever virus and Chikungunya virus. Recently, dramatic changes in the transcriptome of Ae. aegypti following a blood meal have been reported; however, the molecular factors involved in regulating these changes are largely unknown. In this study, we found induction of a number of endogenous microRNAs (miRNAs) in blood fed (BF) mosquitoes. One of these miRNAs, aae-miR-375, was only detected in BF mosquitoes. Based on target analyses, we found six different genes involved in development and immunity being regulated by aae-miR-375 at the post-transcriptional level. We further confirmed the specific interaction of aae-miR-375 with the target sequences in the transcripts of two immune related genes, cactus and REL1, using a GFP-based reporter assay. Overall, results from this report indicate that miRNAs induced upon blood feeding can regulate the transcript levels of several genes that are important in development and immune responses in mosquitoes. In addition, we demonstrate that aae-miR-375 enhances Dengue virus serotype 2 (DENV-2) infection in an Ae. aegypti cell line. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| United Kingdom | 2 | 1% |
| Japan | 1 | <1% |
| Malaysia | 1 | <1% |
| Unknown | 129 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 30 | 22% |
| Student > Ph. D. Student | 22 | 16% |
| Student > Master | 16 | 12% |
| Student > Bachelor | 13 | 10% |
| Student > Doctoral Student | 9 | 7% |
| Other | 25 | 18% |
| Unknown | 21 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 50 | 37% |
| Biochemistry, Genetics and Molecular Biology | 33 | 24% |
| Immunology and Microbiology | 8 | 6% |
| Medicine and Dentistry | 7 | 5% |
| Nursing and Health Professions | 3 | 2% |
| Other | 12 | 9% |
| Unknown | 23 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 November 2012.
All research outputs
#20,655,488
of 25,373,627 outputs
Outputs from Insect Biochemistry & Molecular Biology
#1,190
of 1,464 outputs
Outputs of similar age
#226,482
of 285,945 outputs
Outputs of similar age from Insect Biochemistry & Molecular Biology
#11
of 13 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,464 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
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We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.