| Title |
Noise-Induced Inner Hair Cell Ribbon Loss Disturbs Central Arc Mobilization: A Novel Molecular Paradigm for Understanding Tinnitus
|
|---|---|
| Published in |
Molecular Neurobiology, November 2012
|
| DOI | 10.1007/s12035-012-8372-8 |
| Pubmed ID | |
| Authors |
Wibke Singer, Annalisa Zuccotti, Mirko Jaumann, Sze Chim Lee, Rama Panford-Walsh, Hao Xiong, Ulrike Zimmermann, Christoph Franz, Hyun-Soon Geisler, Iris Köpschall, Karin Rohbock, Ksenya Varakina, Sandrine Verpoorten, Thomas Reinbothe, Thomas Schimmang, Lukas Rüttiger, Marlies Knipper |
| Abstract |
Increasing evidence shows that hearing loss is a risk factor for tinnitus and hyperacusis. Although both often coincide, a causal relationship between tinnitus and hyperacusis has not been shown. Currently, tinnitus and hyperacusis are assumed to be caused by elevated responsiveness in subcortical circuits. We examined both the impact of different degrees of cochlear damage and the influence of stress priming on tinnitus induction. We used (1) a behavioral animal model for tinnitus designed to minimize stress, (2) ribbon synapses in inner hair cells (IHCs) as a measure for deafferentation, (3) the integrity of auditory brainstem responses (ABR) to detect differences in stimulus-evoked neuronal activity, (4) the expression of the activity-regulated cytoskeletal protein, Arc, to identify long-lasting changes in network activity within the basolateral amygdala (BLA), hippocampal CA1, and auditory cortex (AC), and (5) stress priming to investigate the influence of corticosteroid on trauma-induced brain responses. We observed that IHC ribbon loss (deafferentation) leads to tinnitus when ABR functions remain reduced and Arc is not mobilized in the hippocampal CA1 and AC. If, however, ABR waves are functionally restored and Arc is mobilized, tinnitus does not occur. Both central response patterns were found to be independent of a profound threshold loss and could be shifted by the corticosterone level at the time of trauma. We, therefore, discuss the findings in the context of a history of stress that can trigger either an adaptive or nonadaptive brain response following injury. |
Mendeley readers
The data shown below were compiled from readership statistics for 118 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Spain | 1 | <1% |
| Canada | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 113 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 24 | 20% |
| Student > Ph. D. Student | 23 | 19% |
| Student > Bachelor | 18 | 15% |
| Student > Master | 11 | 9% |
| Other | 7 | 6% |
| Other | 15 | 13% |
| Unknown | 20 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 25% |
| Agricultural and Biological Sciences | 23 | 19% |
| Neuroscience | 20 | 17% |
| Nursing and Health Professions | 4 | 3% |
| Biochemistry, Genetics and Molecular Biology | 4 | 3% |
| Other | 14 | 12% |
| Unknown | 24 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2012.
All research outputs
#15,256,901
of 22,687,320 outputs
Outputs from Molecular Neurobiology
#2,039
of 3,430 outputs
Outputs of similar age
#100,287
of 159,110 outputs
Outputs of similar age from Molecular Neurobiology
#9
of 15 outputs
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