Title |
Vironome of Kaposi sarcoma associated herpesvirus-inflammatory cytokine syndrome in an AIDS patient reveals co-infection of human herpesvirus 8 and human herpesvirus 6A
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Published in |
Virology, August 2012
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DOI | 10.1016/j.virol.2012.08.014 |
Pubmed ID | |
Authors |
Kristen M. Tamburro, Dongmei Yang, Jessica Poisson, Yuri Fedoriw, Debasmita Roy, Amy Lucas, Sang-Hoon Sin, Nadia Malouf, Vincent Moylan, Blossom Damania, Stephan Moll, Charles van der Horst, Dirk P. Dittmer |
Abstract |
KSHV inflammatory cytokine syndrome (KICS) is a newly described condition characterized by systemic illness as a result of systemic, lytic KSHV infection. We used Illumina sequencing to establish the DNA vironome of blood from such a patient. It identified concurrent high-level viremia of human herpesvirus (HHV) 8 and 6a. The HHV8 plasma viral load was 5,300,000 copies/ml, which is the highest reported to date; this despite less than five skin lesions and no HHV8 associated lymphoma. This is the first report of systemic HHV6a/KSHV co-infection in a patient. It is the first whole genome KSHV sequence to be determined directly from patient plasma rather than cultured or biopsied tumor material. This case supports KICS as a new clinical entity associated with KSHV. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
Panama | 1 | 33% |
Netherlands | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 5% |
France | 1 | 2% |
Unknown | 41 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 20% |
Student > Ph. D. Student | 8 | 18% |
Student > Postgraduate | 5 | 11% |
Student > Master | 4 | 9% |
Professor | 3 | 7% |
Other | 7 | 16% |
Unknown | 8 | 18% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 17 | 39% |
Medicine and Dentistry | 12 | 27% |
Biochemistry, Genetics and Molecular Biology | 4 | 9% |
Immunology and Microbiology | 1 | 2% |
Veterinary Science and Veterinary Medicine | 1 | 2% |
Other | 0 | 0% |
Unknown | 9 | 20% |