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A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing

Overview of attention for article published in Molecular Psychiatry, December 2012
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

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2 policy sources
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4 X users
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1 Wikipedia page

Citations

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148 Dimensions

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199 Mendeley
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1 CiteULike
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Title
A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing
Published in
Molecular Psychiatry, December 2012
DOI 10.1038/mp.2012.159
Pubmed ID
Authors

G Davies, S E Harris, C A Reynolds, A Payton, H M Knight, D C Liewald, L M Lopez, M Luciano, A J Gow, J Corley, R Henderson, C Murray, A Pattie, H C Fox, P Redmond, M W Lutz, O Chiba-Falek, C Linnertz, S Saith, P Haggarty, G McNeill, X Ke, W Ollier, M Horan, A D Roses, C P Ponting, D J Porteous, A Tenesa, A Pickles, J M Starr, L J Whalley, N L Pedersen, N Pendleton, P M Visscher, I J Deary

Abstract

Cognitive decline is a feared aspect of growing old. It is a major contributor to lower quality of life and loss of independence in old age. We investigated the genetic contribution to individual differences in nonpathological cognitive ageing in five cohorts of older adults. We undertook a genome-wide association analysis using 549 692 single-nucleotide polymorphisms (SNPs) in 3511 unrelated adults in the Cognitive Ageing Genetics in England and Scotland (CAGES) project. These individuals have detailed longitudinal cognitive data from which phenotypes measuring each individual's cognitive changes were constructed. One SNP--rs2075650, located in TOMM40 (translocase of the outer mitochondrial membrane 40 homolog)--had a genome-wide significant association with cognitive ageing (P=2.5 × 10(-8)). This result was replicated in a meta-analysis of three independent Swedish cohorts (P=2.41 × 10(-6)). An Apolipoprotein E (APOE) haplotype (adjacent to TOMM40), previously associated with cognitive ageing, had a significant effect on cognitive ageing in the CAGES sample (P=2.18 × 10(-8); females, P=1.66 × 10(-11); males, P=0.01). Fine SNP mapping of the TOMM40/APOE region identified both APOE (rs429358; P=3.66 × 10(-11)) and TOMM40 (rs11556505; P=2.45 × 10(-8)) as loci that were associated with cognitive ageing. Imputation and conditional analyses in the discovery and replication cohorts strongly suggest that this effect is due to APOE (rs429358). Functional genomic analysis indicated that SNPs in the TOMM40/APOE region have a functional, regulatory non-protein-coding effect. The APOE region is significantly associated with nonpathological cognitive ageing. The identity and mechanism of one or multiple causal variants remain unclear.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 199 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
United Kingdom 3 2%
Germany 2 1%
Switzerland 1 <1%
Hungary 1 <1%
Austria 1 <1%
Spain 1 <1%
Canada 1 <1%
Unknown 186 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 42 21%
Researcher 37 19%
Student > Master 29 15%
Professor > Associate Professor 13 7%
Student > Bachelor 13 7%
Other 34 17%
Unknown 31 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 40 20%
Psychology 27 14%
Medicine and Dentistry 26 13%
Biochemistry, Genetics and Molecular Biology 21 11%
Neuroscience 17 9%
Other 30 15%
Unknown 38 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2023.
All research outputs
#3,048,127
of 24,875,365 outputs
Outputs from Molecular Psychiatry
#2,003
of 4,483 outputs
Outputs of similar age
#29,172
of 289,453 outputs
Outputs of similar age from Molecular Psychiatry
#12
of 40 outputs
Altmetric has tracked 24,875,365 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,483 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.2. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 289,453 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.