Title |
Risperidone Dosing in Children and Adolescents with Autistic Disorder: A Double-Blind, Placebo-Controlled Study
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Published in |
Journal of Autism and Developmental Disorders, December 2012
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DOI | 10.1007/s10803-012-1723-5 |
Pubmed ID | |
Authors |
Justine M. Kent, Stuart Kushner, Xiaoping Ning, Keith Karcher, Seth Ness, Michael Aman, Jaskaran Singh, David Hough |
Abstract |
Efficacy and safety of 2 risperidone doses were evaluated in children and adolescents with autism. Patients (N = 96; 5-17 years), received risperidone (low-dose: 0.125 mg/day [20 to <45 kg], 0.175 mg/day [>45 kg] or high-dose: 1.25 mg/day [20 to <45 kg], 1.75 mg/day [>45 kg]) or placebo. Mean baseline (range 27-29) to endpoint change in Aberrant Behavior Checklist-Irritability (primary endpoint) was significantly greater in the high-dose-(-12.4 [6.5]; p < 0.001), but not low-dose (-7.4 [8.1]; p = 0.164) group, versus placebo (-3.5 [10.7]). Clinical Global Impressions-Severity and Children's Yale-Brown Obsessive Compulsive Scale scores improved significantly only in the high-dose group, consistent with ABC-I results. Somnolence, sedation and increased appetite occurred more frequently in high-versus low-dose groups. Overall, increased appetite occurred most frequently. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 25% |
United Kingdom | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Jordan | 1 | <1% |
United States | 1 | <1% |
France | 1 | <1% |
Germany | 1 | <1% |
Unknown | 154 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 23 | 15% |
Researcher | 20 | 13% |
Student > Ph. D. Student | 16 | 10% |
Student > Bachelor | 15 | 9% |
Student > Doctoral Student | 11 | 7% |
Other | 34 | 22% |
Unknown | 39 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 41 | 26% |
Psychology | 26 | 16% |
Pharmacology, Toxicology and Pharmaceutical Science | 14 | 9% |
Agricultural and Biological Sciences | 8 | 5% |
Nursing and Health Professions | 6 | 4% |
Other | 19 | 12% |
Unknown | 44 | 28% |