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Multiplicity and Molecular Heterogeneity of Colorectal Carcinomas in Individuals With Serrated Polyposis

Overview of attention for article published in The American Journal of Surgical Pathology, March 2013
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  • Good Attention Score compared to outputs of the same age (66th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (51st percentile)

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Title
Multiplicity and Molecular Heterogeneity of Colorectal Carcinomas in Individuals With Serrated Polyposis
Published in
The American Journal of Surgical Pathology, March 2013
DOI 10.1097/pas.0b013e318270f748
Pubmed ID
Authors

Christophe Rosty, Michael D. Walsh, Rhiannon J. Walters, Mark Clendenning, Sally-Ann Pearson, Mark A. Jenkins, Aung Ko Win, John L. Hopper, Kevin Sweet, Wendy L. Frankel, Melyssa Aronson, Steve Gallinger, Jack Goldblatt, Kathy Tucker, Sian Greening, Michael R. Gattas, Sonja Woodall, Julie Arnold, Neal I. Walker, Susan Parry, Joanne P. Young, Daniel D. Buchanan

Abstract

Serrated polyposis (SP) is a clinically defined syndrome characterized by the occurrence of multiple serrated polyps in the large intestine. Individuals with SP and their relatives are at increased risk of colorectal carcinoma (CRC). We aimed to determine the pathologic and molecular profiles of CRCs in individuals fulfilling World Health Organization criteria for SP. A total of 45 CRCs were obtained from 38 individuals with SP (27 female and 11 male patients; median age at CRC diagnosis, 58.5 y) attending genetics clinics. Tumor samples were pathologically reviewed, screened for somatic BRAF and KRAS mutations, and analyzed immunohistochemically for mismatch repair protein (MMR) expression. Tumors were spread throughout the large intestine, with 64% located in the proximal colon. Mutations in BRAF and KRAS and immunohistochemical evidence of MMR deficiency were found in 46%, 5%, and 38%, respectively. Nearly half of CRCs were BRAF/KRAS wild type, and these were associated with distal location (63%) and MMR proficiency (84%). Overexpression of p53 and/or evidence of β-catenin activation were identified in 13 CRCs. Ten patients (26%) had synchronous or metachronous CRCs. In conclusion, the majority of CRCs arising in individuals with SP do not harbor molecular hallmarks of serrated pathway CRCs but show a diverse range of molecular profiles. The high proportion of multiple CRCs suggests that individuals with SP would benefit from frequent colonoscopic surveillance and from a consideration of a more extensive colectomy at the time of CRC diagnosis.

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The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 5%
Unknown 39 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 27%
Professor > Associate Professor 5 12%
Student > Doctoral Student 5 12%
Student > Postgraduate 3 7%
Student > Ph. D. Student 3 7%
Other 7 17%
Unknown 7 17%
Readers by discipline Count As %
Medicine and Dentistry 25 61%
Agricultural and Biological Sciences 5 12%
Social Sciences 2 5%
Chemistry 1 2%
Engineering 1 2%
Other 0 0%
Unknown 7 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 April 2013.
All research outputs
#8,262,445
of 25,374,917 outputs
Outputs from The American Journal of Surgical Pathology
#1,507
of 3,522 outputs
Outputs of similar age
#67,559
of 206,326 outputs
Outputs of similar age from The American Journal of Surgical Pathology
#20
of 41 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 3,522 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 206,326 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.