Title |
Serum CD163 and TARC as Disease Response Biomarkers in Classical Hodgkin Lymphoma
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Published in |
Clinical Cancer Research, January 2013
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DOI | 10.1158/1078-0432.ccr-12-2693 |
Pubmed ID | |
Authors |
Kimberley Jones, Frank Vari, Colm Keane, Pauline Crooks, Jamie P. Nourse, Louise A. Seymour, David Gottlieb, David Ritchie, Devinder Gill, Maher K. Gandhi |
Abstract |
Candidate circulating disease response biomarkers for classical Hodgkin lymphoma (cHL) might arise from Hodgkin-Reed-Sternberg (HRS) cells or nonmalignant tumor-infiltrating cells. HRS cells are sparse within the diseased node, whereas benign CD163(+) M2 tissue-associated macrophages (TAM) are prominent. CD163(+) cells within the malignant node may be prognostic, but there is no data on serum CD163 (sCD163). The HRS-specific serum protein sTARC shows promise as a disease response biomarker. Tumor-specific and tumor-infiltrating circulating biomarkers have not been compared previously. |
X Demographics
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 1% |
Netherlands | 1 | 1% |
Unknown | 80 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 13 | 16% |
Student > Bachelor | 13 | 16% |
Student > Ph. D. Student | 10 | 12% |
Other | 7 | 9% |
Student > Master | 7 | 9% |
Other | 20 | 24% |
Unknown | 12 | 15% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 35 | 43% |
Agricultural and Biological Sciences | 12 | 15% |
Immunology and Microbiology | 8 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Biochemistry, Genetics and Molecular Biology | 2 | 2% |
Other | 7 | 9% |
Unknown | 15 | 18% |