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Mendeley readers
Attention Score in Context
| Title |
Refining genome-wide linkage intervals using a meta-analysis of genome-wide association studies identifies loci influencing personality dimensions
|
|---|---|
| Published in |
European Journal of Human Genetics, December 2012
|
| DOI | 10.1038/ejhg.2012.263 |
| Pubmed ID | |
| Authors |
Najaf Amin, Jouke-Jan Hottenga, Narelle K Hansell, A Cecile JW Janssens, Marleen HM de Moor, Pamela AF Madden, Irina V Zorkoltseva, Brenda W Penninx, Antonio Terracciano, Manuela Uda, Toshiko Tanaka, Tonu Esko, Anu Realo, Luigi Ferrucci, Michelle Luciano, Gail Davies, Andres Metspalu, Goncalo R Abecasis, Ian J Deary, Katri Raikkonen, Laura J Bierut, Paul T Costa, Viatcheslav Saviouk, Gu Zhu, Anatoly V Kirichenko, Aaron Isaacs, Yurii S Aulchenko, Gonneke Willemsen, Andrew C Heath, Michele L Pergadia, Sarah E Medland, Tatiana I Axenovich, Eco de Geus, Grant W Montgomery, Margaret J Wright, Ben A Oostra, Nicholas G Martin, Dorret I Boomsma, Cornelia M van Duijn |
| Abstract |
Personality traits are complex phenotypes related to psychosomatic health. Individually, various gene finding methods have not achieved much success in finding genetic variants associated with personality traits. We performed a meta-analysis of four genome-wide linkage scans (N=6149 subjects) of five basic personality traits assessed with the NEO Five-Factor Inventory. We compared the significant regions from the meta-analysis of linkage scans with the results of a meta-analysis of genome-wide association studies (GWAS) (N∼17 000). We found significant evidence of linkage of neuroticism to chromosome 3p14 (rs1490265, LOD=4.67) and to chromosome 19q13 (rs628604, LOD=3.55); of extraversion to 14q32 (ATGG002, LOD=3.3); and of agreeableness to 3p25 (rs709160, LOD=3.67) and to two adjacent regions on chromosome 15, including 15q13 (rs970408, LOD=4.07) and 15q14 (rs1055356, LOD=3.52) in the individual scans. In the meta-analysis, we found strong evidence of linkage of extraversion to 4q34, 9q34, 10q24 and 11q22, openness to 2p25, 3q26, 9p21, 11q24, 15q26 and 19q13 and agreeableness to 4q34 and 19p13. Significant evidence of association in the GWAS was detected between openness and rs677035 at 11q24 (P-value=2.6 × 10(-06), KCNJ1). The findings of our linkage meta-analysis and those of the GWAS suggest that 11q24 is a susceptible locus for openness, with KCNJ1 as the possible candidate gene. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Russia | 1 | 20% |
| Australia | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 1% |
| Unknown | 72 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 17 | 23% |
| Student > Ph. D. Student | 12 | 16% |
| Professor | 8 | 11% |
| Student > Bachelor | 8 | 11% |
| Student > Master | 8 | 11% |
| Other | 10 | 14% |
| Unknown | 10 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 18 | 25% |
| Agricultural and Biological Sciences | 18 | 25% |
| Medicine and Dentistry | 8 | 11% |
| Biochemistry, Genetics and Molecular Biology | 6 | 8% |
| Neuroscience | 5 | 7% |
| Other | 7 | 10% |
| Unknown | 11 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2023.
All research outputs
#7,224,201
of 23,879,989 outputs
Outputs from European Journal of Human Genetics
#1,704
of 3,532 outputs
Outputs of similar age
#74,491
of 283,813 outputs
Outputs of similar age from European Journal of Human Genetics
#16
of 42 outputs
Altmetric has tracked 23,879,989 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 3,532 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.2. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 283,813 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.